Humphries, Fiachra and Moynagh, Paul N. (2015) Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity. Immunological Reviews, 266 (1). pp. 93-108. ISSN 1600-065X

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Abstract

The sensing of foreign agents by the innate and adaptive immune system triggers complex signal transduction cascades that culminate in expression of gene patterns that facilitate host protection from the invading agent. Post‐translational modification of intracellular signaling proteins in these pathways is a key regulatory mechanism with ubiquitination being one of the important processes that controls levels and activities of signaling molecules. E3 ubiquitin ligases are the determining enzymes in dictating the ubiquitination status of individual proteins. Among these hundred E3 ubiquitin ligases are a family of Pellino proteins that are emerging to be important players in immunity and beyond. Herein, we review the roles of the Pellino E3 ubiquitin ligases in innate and adaptive immunity. We discuss their early discovery and characterization and how this has been aided by the highly conserved nature of innate immune signaling across evolution. We describe the molecular roles of Pellino proteins in immune signaling with particular emphasis on their involvement in pathogen recognition receptor (PRR) signaling. The growing appreciation of the importance of Pellino proteins in a wide range of immune‐mediated diseases are also evaluated.

Item Type:	Article
Keywords:	Pellino E3 ubiquitin ligases; innate immunity; Toll-like receptors; NODlike receptors; inflammation; ubiquitination;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Institute of Immunology
Item ID:	11042
Identification Number:	https://doi.org/10.1111/imr.12306
Depositing User:	Professor Paul Moynagh
Date Deposited:	16 Sep 2019 14:22
Journal or Publication Title:	Immunological Reviews
Publisher:	Wiley
Refereed:	Yes
Funders:	Science Foundation Ireland (SFI)
URI:	https://onlinelibrary.wiley.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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