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    Innate humoral immune defences in mammals and insects: The same, with differences ?

    Sheehan, Gerard and Garvey, Amy and Croke, Michael and Kavanagh, Kevin (2018) Innate humoral immune defences in mammals and insects: The same, with differences ? Virulence, 9 (1). pp. 1625-1639. ISSN 2150-5608

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    The insect immune response demonstrates many similarities to the innate immune response of mammals and a wide range of insects is now employed to assess the virulence of pathogens and produce results comparable to those obtained using mammals. Many of the humoral responses in insects and mammals are similar (e.g. insect transglutaminases and human clotting factor XIIIa) however a number show distinct differences. For example in mammals, melanization plays a role in protection from solar radiation and in skin and hair pigmentation. In contrast, insect melanization acts as a defence mechanism in which the proPO system is activated upon pathogen invasion. Human and insect antimicrobial peptides share distinct structural and functional similarities, insects produce the majority of their AMPs from the fat body while mammals rely on production locally at the site of infection by epithelial/mucosal cells. Understanding the structure and function of the insect immune system and the similarities with the innate immune response of mammals will increase the attractiveness of using insects as in vivo models for studying host – pathogen interactions.

    Item Type: Article
    Additional Information: © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cite as: Gerard Sheehan, Amy Garvey, Michael Croke & Kevin Kavanagh (2018) Innate humoral immune defences in mammals and insects: The same, with differences ?, Virulence, 9:1, 1625-1639, DOI: 10.1080/21505594.2018.1526531
    Keywords: Antimicrobial peptide; coagulation; humoral immunity; insect; mammal; melanization; Toll;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 11067
    Identification Number:
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 20 Sep 2019 16:12
    Journal or Publication Title: Virulence
    Publisher: Taylor & Francis Open
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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