Cotter, Gary and Wheedle, Roisin and Kavanagh, Kevin
(1998)
Monoclonal antibodies directed against extracellular matrix proteins reduce the adherence of Candida albicans to HEp-2 cells.
Mycopathologia, 141 (3).
pp. 137-142.
ISSN 1573-0832
Abstract
The presence of the extracellular matrix (ECM) proteins collagen types I and IV, laminin and fibronectin on the surface of HEp-2 cells was confirmed by flow cytometry using monoclonal antibodies. Monoclonal antibodies directed against these ECM proteins reduced the adherence of C. albicans ATCC 44990 to HEp-2 cells, the greatest reductions being evident in assays which incorporated anti-collagen type IV monoclonal antibody. The ability of sugaramines to inhibit the adherence of C. albicans to a variety of cell types has been demonstrated previously and the most significant reduction in C. albicans – HEp-2 adherence was in assays which incorporated 0.2M galactosamine. The combination of anti-collagen IV monoclonal antibody and galactosamine reduced the adherence of C. albicans to HEp-2 cells by approximately 70% (p < 0.05).
Item Type: |
Article
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Additional Information: |
Cite as: Cotter, G., Weedle, R. & Kavanagh, K. Mycopathologia (1998) 141: 137. https://doi.org/10.1023/A:1006940203962 |
Keywords: |
Adherence; Candida; Extracellular matrix; HEp-2; |
Academic Unit: |
Faculty of Science and Engineering > Biology |
Item ID: |
11120 |
Identification Number: |
https://doi.org/10.1023/A:1006940203962 |
Depositing User: |
Dr. Kevin Kavanagh
|
Date Deposited: |
03 Oct 2019 14:26 |
Journal or Publication Title: |
Mycopathologia |
Publisher: |
Kluwer Academic Publishers |
Refereed: |
Yes |
URI: |
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Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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