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    Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy


    Khan, Faheem and Mat, Arimin and Hogan, Andrew and Kent, Brian D. and Eigenheer, Sonia and Corrigan, Michelle and O'Shea, Donal and Butler, Marcus W. (2017) Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy. QJM: An International Journal of Medicine, 110 (12). pp. 853-854. ISSN 1460-2725

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    Abstract

    The QJM has recently published reviews of novel therapies in chronic airways disease.1 There is a potentially novel role for glucagon-like peptide 1 (GLP-1) agonists in obesity-related, metabolic asthma, though clinical trial data are lacking.2 On the basis of work with other inflammatory states, we hypothesised that clinically-indicated use of GLP-1 agonists for glycaemic control in type 2 diabetes mellitus (T2DM) would be safe in those with concomitant asthma, potentially leading to improved asthma control and fewer asthma exacerbations.3 In a pilot observational cohort study, we prospectively identified nine patients with pulmonologist-diagnosed asthma (never-smokers) and concomitant T2DM who were about to be initiated on clinically-indicated liraglutide for T2DM in the course of routine clinical care, and assessed them for asthma-related indices at baseline and 52 weeks after initiating liraglutide. All received routine asthma care. Baseline characteristics of the study cohort are as shown (Table 1)...

    Item Type: Article
    Keywords: Medicine, general & internat; Receptor; obesity; Asthma;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 11565
    Identification Number: https://doi.org/10.1093/qjmed/hcx125
    Depositing User: Andrew Hogan
    Date Deposited: 01 Nov 2019 16:45
    Journal or Publication Title: QJM: An International Journal of Medicine
    Publisher: Oxford University Press
    Refereed: Yes
    URI:

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