Khan, Faheem and Mat, Arimin and Hogan, Andrew and Kent, Brian D. and Eigenheer, Sonia and Corrigan, Michelle and O'Shea, Donal and Butler, Marcus W. (2017) Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy. QJM: An International Journal of Medicine, 110 (12). pp. 853-854. ISSN 1460-2725

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Abstract

The QJM has recently published reviews of novel therapies in chronic airways disease.1 There is a potentially novel role for glucagon-like peptide 1 (GLP-1) agonists in obesity-related, metabolic asthma, though clinical trial data are lacking.2 On the basis of work with other inflammatory states, we hypothesised that clinically-indicated use of GLP-1 agonists for glycaemic control in type 2 diabetes mellitus (T2DM) would be safe in those with concomitant asthma, potentially leading to improved asthma control and fewer asthma exacerbations.3 In a pilot observational cohort study, we prospectively identified nine patients with pulmonologist-diagnosed asthma (never-smokers) and concomitant T2DM who were about to be initiated on clinically-indicated liraglutide for T2DM in the course of routine clinical care, and assessed them for asthma-related indices at baseline and 52 weeks after initiating liraglutide. All received routine asthma care. Baseline characteristics of the study cohort are as shown (Table 1)...

Item Type:	Article
Keywords:	Medicine, general & internat; Receptor; obesity; Asthma;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	11565
Identification Number:	https://doi.org/10.1093/qjmed/hcx125
Depositing User:	Andrew Hogan
Date Deposited:	01 Nov 2019 16:45
Journal or Publication Title:	QJM: An International Journal of Medicine
Publisher:	Oxford University Press
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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