Taynnan Barros, Michael and Dey, Subhrakanti (2017) Set point regulation of astrocyte intracellular Ca2+signalling. In: 2017 IEEE 17th International Conference on Nanotechnology (IEEE-NANO). IEEE, pp. 315-320. ISBN 978-1-5090-3028-6

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Abstract

Neurodegenerative diseases are the current centre of attention in medicine due to their increased physiological and psychological burden on the ageing society and in the other hand the lack of efficient treatment to them. In parallel, nanotechnology opens possibilities to study neurodegeneration in the molecular level and uncover cellular properties at the nanoscale that possibly allow disease control using novel system biology methods. The communication between neurons and astrocytes explains how a failure in their communication impact neuronal activity, and how the intracellular Ca 2+ signalling of astrocytes can interfere in the synaptic quality. This paper presents a theoretical investigation of a feedforward and feedback control technique to regulate the quantity of IP3 that determines the concentration of Ca 2+ emitted from intracellular signalling. The analysis of the control model showed that the quantity of Ca 2+ signalling can be stabilised at a desired level. A potential application is to facilitate the Ca 2+ concentration around this desired level to maintain cellular homoeostasis for longer periods of time, which can lead to a technology for preventing neurodegenerative diseases. The proposed approach can result in novel solutions for both nanobiology and nanomedicine development, where synthetic biology can be used to program the control functionality into the cells. Other ways of implementing such technology are also explored, including nanoparticles, implantable devices and molecular communications.

Item Type:	Book Section
Additional Information:	The 2017 IEEE 17th International Conference on Nanotechnology (IEEE-NANO) was held in Pittsburgh, PA, USA from 25 to 28 July 2017
Keywords:	Calcium; Calcium compounds; Disease control; Implants (surgical); Medical nanotechnology; Nanotechnology; Neurons; Physiology; Cellular properties; Control functionality; Feedforward and feedback control; Implantable devices; Intracellular signalling; Molecular communication; Set-point regulation; Theoretical investigations; Neurodegenerative diseases;
Academic Unit:	Faculty of Science and Engineering > Electronic Engineering Faculty of Science and Engineering > Research Institutes > Hamilton Institute
Item ID:	11897
Identification Number:	https://doi.org/10.1109/NANO.2017.8117306
Depositing User:	Subhrakanti Dey
Date Deposited:	28 Nov 2019 11:59
Publisher:	IEEE
Refereed:	Yes
URI:	Publisher Organisation
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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