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    BCL46 and other genomic alterations in non-Hodgkin's lymphoma (NHL)

    Butler, Marion P. and Corbally, N. and Dervan, P.A. and Carney, D.N. (1997) BCL46 and other genomic alterations in non-Hodgkin's lymphoma (NHL). British Journal of Cancer, 75 (11). pp. 1641-1645. ISSN 1532-1827

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    This study reports on the frequency and disease association pattern of a number of gene rearrangements in a large panel of lymphoid tumours (n = 94). We detected the t(11;14) translocation, involving rearrangement of the BCL - 1 locus, in 60% of mantle cell lymphomas. The BCL - 2 gene, located at band 18q21, was rearranged in 42% of follicle centre lymphomas (FCL) and in 15% of diffuse large B-cell (DLBC) lymphomas. In this study, 80% of the c-MYC rearrangements were detected in aggressive diffuse lymphoma subsets but, interestingly, 9% of FCL showed involvement of t(8q24) translocation. In our study, rearrangements of the BCL-6 gene at band 3q27 were found in 31% of DLBC lymphomas. Interestingly, 50% of the BCL-6 rearrangement positive lymphoma cases had coexisting gene rearrangements involving all of the aforementioned gene loci. The molecular dissection of these genes will improve our understanding of the genesis of the diverse clinicopathological subtypes.

    Item Type: Article
    Keywords: lymphoma; BCL-6; gene rearrangements; non-Hodgkin's lymphoma; genomic alterations;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12362
    Depositing User: Marion Butler
    Date Deposited: 04 Feb 2020 16:48
    Journal or Publication Title: British Journal of Cancer
    Publisher: Cancer Research UK
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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