Hams, Emily and Bermingham, Rachel and Wurlod, Felicity A. and Hogan, Andrew E. and O'Shea, Donal and Preston, Roger J. and Rodewald, Hans-Reimer and McKenzie, Andrew N.J. and Fallon, Padraic G. (2016) The helminth T2 RNase v1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism. The FASEB Journal, 30. pp. 824-835. ISSN 0892-6638

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Abstract

Induction of a type 2 cellular response in the white adipose tissue leads to weight loss and improves glucose homeostasis in obese animals. Injection of obese mice with recombinant helminth-derived Schistosoma mansoni egg-derived v1 (v1), a potent inducer of type 2 activation, improves metabolic status involving a mechanism reliant upon release of the type 2 initiator cytokine IL-33. IL-33 initiates the accumulation of group 2 innate lymphoid cells (ILC2s), eosinophils, and alternatively activated macrophages in the adipose tissue. IL-33 release from cells in the adipose tissue is mediated by the RNase activity of v1; however, the ability of v1 to improve metabolic status is reliant upon effective binding of v1 to CD206. We demonstrate a novel mechanism for RNasemediated release of IL-33 inducing ILC2-dependent improvements in the metabolic status of obese animals.— Hams, E., Bermingham, R., Wurlod, F. A., Hogan, A. E., O’Shea, D., Preston, R. J., Rodewald, H.-R., McKenzie, A. N. J., Fallon, P. G. The helminth T2 RNase v1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism.

Item Type:	Article
Keywords:	obesity; adipocytes; inflammation;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	12402
Identification Number:	https://doi.org/10.1096/fj.15-277822
Depositing User:	Andrew Hogan
Date Deposited:	10 Feb 2020 17:44
Journal or Publication Title:	The FASEB Journal
Publisher:	Federation of American Society of Experimental Biology
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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