Brandon, Jonathan L. and Schroeder, Shauna and Furuta, Glenn T. and Capocelli, Kelley E. and Masterson, Joanne C. and Fenton, Laura Z. (2013) CT imaging features of eosinophilic colitis in children. Pediatric Radiology, 43 (6). pp. 697-702. ISSN 1432-1998

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Abstract

Background Eosinophilic colitis (EC) is a gastrointestinal disease of undetermined etiology whose clinical features overlap with those of the inflammatory bowel diseases. To the best of our knowledge, the CT imaging features of EC have not been described in children. Objective To report and analyze the clinical, imaging and histological findings in seven children with EC. Materials and methods Children with EC were identified in a pediatric pathology database, and those with CT imaging within 2 months of diagnosis were included, totaling seven children. Clinical, imaging and pathological features were reviewed and analyzed. Results The most common presenting symptoms were abdominal pain, bloody diarrhea and rectal bleeding. EC was characterized as a dense and predominantly eosinophilic inflammatory infiltrate in the lamina propria or epithelium without granulomas. CT scans were abnormal in six children (86%), demonstrating colonic wall thickening, predominantly cecal, in five (71%), mild to moderate terminal ileal thickening in two (29%), and pneumatosis in one (14%). Right colonic involvement was greater than terminal ileal involvement. Conclusion CT imaging findings in children with EC include right colonic wall thickening of variable extent downstream and absent or mild involvement of the terminal ileum. EC should be considered in the differential diagnosis in children presenting with abdominal pain and bloody diarrhea

Item Type:	Article
Keywords:	Eosinophilic; Colitis; CT; Inflammatory bowel disease; Allergy; Eosinophilic gastrointestinal disease; Children;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	12490
Identification Number:	https://doi.org/10.1007/s00247-012-2615-8
Depositing User:	Joanne Masterson
Date Deposited:	26 Feb 2020 16:44
Journal or Publication Title:	Pediatric Radiology
Publisher:	Springer Verlag
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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