Kagalwalla, Amir F. and Akhtar, Noorain and Woodruff, Samantha A. and Rea, Bryan A. and Masterson, Joanne C. and Mukkada, Vince and Parashette, Kalyan R. and Du, Jian and Fillon, Sophie A. and Protheroe, Cheryl A. and Lee, James J. and Amsden, Katie and Melin-Aldana, Hector and Capocelli, Kelley E. and Furuta, Glenn T. and Ackerman, Steven J.
(2012)
Eosinophilic esophagitis: Epithelial mesenchymal transition
contributes to esophageal remodeling and reverses with
treatment.
Journal of Allergy and Clinical Immunology, 129 (5).
1387-1396.e7.
ISSN 1097-6825
Abstract
Background: Mechanisms underlying esophageal remodeling
with subepithelial fibrosis in subjects with eosinophilic
esophagitis (EoE) have not been delineated.
Objectives: We sought to explore a role for epithelial
mesenchymal transition (EMT) in subjects with EoE and
determine whether EMT resolves with treatment.
Methods: Esophageal biopsy specimens from 60 children were
immunostained for epithelial (cytokeratin) and mesenchymal
(vimentin) EMT biomarkers, and EMT was quantified.
| Item Type: |
Article
|
| Keywords: |
Eosinophil; esophagitis; epithelium; remodeling; fibrosis; mesenchymal; vimentin; cytokeratin; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
12493 |
| Identification Number: |
https://doi.org/10.1016/j.jaci.2012.03.005 |
| Depositing User: |
Joanne Masterson
|
| Date Deposited: |
27 Feb 2020 15:11 |
| Journal or Publication Title: |
Journal of Allergy and Clinical Immunology |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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