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    Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function

    McNamee, Eóin N. and Korns Johnson, Darlynn and Homann, Dirk and Clambey, Eric T. (2013) Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function. Immunologic Research, 55 (1-3). pp. 58-70. ISSN 1559-0755

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    Oxygen is a molecule that is central to cellular respiration and viability, yet there are multiple physiologic and pathological contexts in which cells experience conditions of insufficient oxygen availability, a state known as hypoxia. Given the metabolic challenges of a low oxygen environment, hypoxia elicits a range of adaptive responses at the cellular, tissue, and systemic level to promote continued survival and function. Within this context, T lymphocytes are a highly migratory cell type of the adaptive immune system that frequently encounters a wide range of oxygen tensions in both health and disease. It is now clear that oxygen availability regulates T cell differentiation and function, a response orchestrated in large part by the hypoxia-inducible factor transcription factors. Here, we discuss the physiologic scope of hypoxia and hypoxic signaling, the contribution of these pathways in regulating T cell biology, and current gaps in our understanding. Finally, we discuss how emerging therapies that modulate the hypoxic response may offer new modalities to alter T cell function and the outcome of acute and chronic pathologies.

    Item Type: Article
    Keywords: T cell; Oxygen; Hypoxia; Hypoxia-inducible factor; Metabolism;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12586
    Identification Number:
    Depositing User: Eoin McNamee
    Date Deposited: 23 Mar 2020 12:12
    Journal or Publication Title: Immunologic Research
    Publisher: Springer
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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