English, Jane A. and Lopez, Lorna and OGorman, Aoife and Focking, Melanie and Hryniewicka, Magdalena and Scaife, Caitriona and Sabherwal, Sophie and Wynne, Kieran and Dicker, Patrick and Rutten, Bart P.F. and Lewis, Glynn and Zammit, Stanley and Cannon, Mary and Cagney, Gerard and Cotter, David R. (2018) Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case–Control Study of the ALSPAC Longitudinal Birth Cohort. Schizophrenia Bulletin, 44 (2). pp. 297-306. ISSN 0586-7614

Preview

Download (9MB) | Preview

Abstract

The identification of early biological changes associated with the psychotic disorder (PD) is important as it may provide clues to the underlying pathophysiological mechanisms. We undertook the first proteomic profiling of blood plasma samples of children who later develop a PD. Participants were recruited from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who also participated in psychiatric assessment interviews at age 18. Protein expression levels at age 11 were compared between individuals who developed PD at age 18 (n = 37) with population-based agematched controls (n = 38). Sixty out of 181 plasma proteins profiled were found to be differentially expressed (P < .05) in children with an outcome of the PD. Thirty-four of these proteins were found to be differentially expressed following correction for multiple comparisons. Pathway analysis implicated the complement and coagulation cascade. A second, targeted proteomic approach was used to verify these findings in age 11 plasma from subjects who reported psychotic experiences at age 18 (n = 40) in comparison to age-matched controls (n = 66). Our findings indicate that the complement and coagulation system is dysregulated in the blood during childhood before the development of the PD.

Item Type:	Article
Keywords:	ALSPAC; complement; coagulation; plasma; proteomics; psychotic disorder; schizophrenia;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	13187
Identification Number:	https://doi.org/10.1093/schbul/sbx075
Depositing User:	Lorna Lopez
Date Deposited:	14 Aug 2020 15:22
Journal or Publication Title:	Schizophrenia Bulletin
Publisher:	Oxford University Press
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads