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    Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits


    Evangelou, Evangelos and Warren, Helen R. and Mosen-Ansorena, David and Mifsud, Borbala and Pazoki, Raha and Gao, He and Ntritsos, Georgios and Dimou, Niki and Cabrera, Claudia and Karaman, Ibrahim and Ng, Fu Liang and Evangelou, Marina and Witkowska, Katarzyna and Tzanis, Evan and Hellwege, Jacklyn and Giri, Ayush and Edwards, Digna R. Velez and Sun, Yan V. and Cho, Kelly and Gaziano, J. Michael and Wilson, Peter W.F. and Tsao, Philip S. and Kovesdy, Csaba P. and Esko, Tonu and Magi, Reedik and Milani, Lili and Almgren, Peter and Boutin, Thibaud and Debette, Stephanie and Ding, Jun and Giulianini, Franco and Holliday, Elizabeth G. and Jackson, Anne U. and Li-Gao, Ruifang and Lin, Wei-Yu and Luan, Jian'an and Mangino, Massimo and Oldmeadow, Christopher and Prins, Bram Peter and Qian, Yong and Sargurupremraj, Muralidharan and Shah, Nabi and Surendran, Praveen and Theriault, Sebastien and Verweij, Niek and Willems, Sara M. and Zhao, Jing-Hua and Amouyel, Phillippe and Connell, John and de Mutsert, Renee and Doney, Alex S.F. and Farrall, Martin and Menni, Cristina and Morris, Andrew D. and Noordam, Raymond and Pare, Guillaume and Poulter, Neil R. and Shields, Denis C. and Stanton, Alice and Thom, Simon and Abecasis, Gonçalo and Amin, Najaf and Arking, Dan E. and Ayers, Kristin L. and Barbieri, Caterina M. and Batini, Chiara and Bis, Joshua C. and Blake, Tineka and Bochud, Murielle and Boehnke, Michael and Boerwinkle, Eric and Boomsma, Dorret I. and Bottinger, Erwin P. and Braund, Peter S. and Brumat, Marco and Campbell, Archie and Campbell, Harry and Chakravarti, Aavinda and Chambers, John C. and Chauhan, Ganesh and Ciullo, Marina and Cocca, Massimiliano and Collins, Francis and Cordell, Heather J. and Davies, Gail and de Borst, Martin H. and de Geus, Eco J. and Deary, Ian J. and Deelen, Joris and Del Greco, M. Fabiola and Demirkale, Cumhur Yusuf and Dörr, Marcus and Ehret, Georg B. and Elosua, Roberto and Enroth, Stefan and Erzurumluoglu, A. Mesut and Ferreira, Teresa and Franberg, Mattias and Franco, Oscar H. and Gandin, Ilaria and Gasparini, Paolo and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Goel, Anuj and Gow, Alan and Gudnason, Vilmundur and Guo, Xiuqing and Gyllensten, Ulf and Hamsten, Anders and Harris, Tamara B. and Harris, Sarah E. and Hartman, Catharina A. and Havulinna, Aki S. and Hicks, Andrew A. and Hofer, Edith and Hofman, Albert and Jottenga, Jouke-Jan and Huffman, Jennifer and Hwang, Shih-Jen and Ingelsson, Erik and James, Alan and Jansen, Rick and Jarvelin, Marjo-Riitta and Joehanes, Roby and Johansson, Asa and Johnson, Adnrew D. and Joshi, Peter K. and Jousilahti, Pekka and Jukema, J. Wouter and Jula, Antti and Kähönen, Mika and Kathiresan, Sekar and Keavney, Bernard D. and Khaw, Kay-Tee and Knekt, Paul and Knight, Joanne and Kolcic, Ivana and Kooner, Jaspal S. and Koskinen, Seppo and Kristiansson, Kati and Kutalik, Zoltan and Laan, Maris and Larson, Marty and Launer, Lenore J. and Lehne, Benjamin and Lehtimäki, Terho and Liewald, David C.M. and Lin, Li and Lind, Lars and Lindgren, Cecilia M. and Liu, YongMei and Loos, Ruth J.F. and Lopez, Lorna and Lu, Yingchang and Lyytikäinen, Leo-Pekka and Mahajan, Anubha and Mamasoula, Chrysovalanto and Marrugat, Jaume and Marten, Jonathan and Milaneschi, Yuri and Morgan, Anna and Morris, Andrew and Morrison, Alanna C. and Munson, Peter J. and Nalls, Mike A. and Nandakumar, Priyanka and Nelson, Christopher P. and Niiranen, Teemu and Nolte, Ilja M. and Nutile, Teresa and Oldehinkel, Albertine J. and Oostra, Ben A. and O'Reilly, Paul F. and Org, Elin and Padmanabhan, Sandosh and Palmas, Walter and Palotie, Aarno and Pattie, Alison and Polasek, Ozren and Pramstaller, Peter P. and Nguyen, Quang Tri and Raitakari, Olli T. and Ren, Meixia and Rettig, Rainer and Rice, Kenneth and Ridker, Paul M. and Ried, Janina S. and Riese, Harriëtte and Ripatti, Samuli and Robino, Antonietta and Rose, Lynda M. and Rotter, Jerome I. and Rudan, Igor and Ruggiero, Daniela and Saba, Yasaman and Sala, Cinzia F. and Salomaa, Veikko and Samani, Nilesh J. and Sarin, Antti-Pekka and Schmidt, Reinhold and Schmidt, Helena and Shrine, Nick and Siscovick, David and Smith, Albert V. and Snieder, Harold and Sõber, Siim and Sorice, Rossella and Starr, John M. and Stott, David and Strachan, David P. and Strawbridge, Rona J. and Sundström, Johan and Swertz, Morris A. and Taylor, Kent D. and Teumer, Alexander and Tobin, Martin D. and Tomaszewski, Maciej and Toniolo, Daniela and Traglia, Michela and Trompet, Stella and Tuomilehto, Jaako and Tzourio, Christophe and Uitterlinden, Andre G. and Vaez, Ahmad and van der Most, Peter J. and van Duijn, Cornelia M. and Vergnaud, Anne-Claire and verwoert, Germaine C. and Vitart, Veronique and Völke, Uwe and Vollenweider, Peter and Vuckovic, Dragana and Watkins, Hugh and Wild, Sarah H. and Willemsen, Gonneke and Wilson, James F. and Wright, Alan F. and Yao, Jie and Zemunik, Tatijana and Zhang, Weihua and Attia, John R. and Butterworth, Adam S. and Chasman, Daniel I. and Conen, David and Cucca, Francesco and Danesh, John and Hayward, Caroline and Howson, Joanna M.M. and Laakso, Markku and Lakatta, Edward G. and Langenberg, Claudia and Melander, Olle and Mook-Kanamor, Dennis O. and Palmer, Colin and Risch, Lorenz and Scott, Robert and Scott, Rodney and Sever, Peter and Spector, Tim D. and van der Harst, Pim and Wareham, Nicholas J. and Zeggini, Eleftheria and Levy, Daniel and Munroe, Patricia B. and Newton-Cheh, Christopher and Brown, Morris J. and Metspalu, Andres and Hung, Adriana M. and O'Donnell, Christopher and Edwards, Todd L. and Psaty, Bruce M. and Tzoulaki, Ioanna and Barnes, Michael R. and Wain, Louise V. and Elliott, Paul and Caulfield, Mark J. (2018) Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10). pp. 1412-1425. ISSN 1061-4036

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    Abstract

    High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic, pulse pressure) to date in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

    Item Type: Article
    Additional Information: This is the preprint version of the published article, which is available at: Evangelou, E., Warren, H.R., Mosen-Ansorena, D. et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet 50, 1412–1425 (2018). https://doi-org.jproxy.nuim.ie/10.1038/s41588-018-0205-x
    Keywords: Genetic analysis; one million people; 535; new loci; blood pressure traits;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 13316
    Identification Number: https://doi.org/10.1038/s41588-018-0205-x
    Depositing User: Lorna Lopez
    Date Deposited: 29 Sep 2020 15:20
    Journal or Publication Title: Nature Genetics
    Publisher: Nature Research
    Refereed: Yes
    URI:

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