Deslyper, Gwendoline and Doherty, Derek G. and Carolan, James C. and Holland, Celia V. (2019) The role of the liver in the migration of parasites of global significance. Parasites & Vectors, 12 (531). ISSN 1756-3305

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Abstract

Many parasites migrate through different tissues during their life-cycle, possibly with the aim to enhance their fitness. This is true for species of three parasite genera of global importance, Ascaris, Schistosoma and Plasmodium, which cause significant global morbidity and mortality. Interestingly, these parasites all incorporate the liver in their lifecycle. The liver has a special immune status being able to preferentially induce tolerance over immunity. This function may be exploited by parasites to evade host immunity, with Plasmodium spp. in particular using this organ for its multiplication. However, hepatic larval attrition occurs in both ascariasis and schistosomiasis. A better understanding of the molecular mechanisms involved in hepatic infection could be useful in developing novel vaccines and therapies for these parasites.

Item Type:	Article
Additional Information:	© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Cite as: Deslyper, G., Doherty, D.G., Carolan, J.C. et al. The role of the liver in the migration of parasites of global significance. Parasites Vectors 12, 531 (2019). https://doi.org/10.1186/s13071-019-3791-2 Funding: This work was supported by the Irish Research Council Postgraduate Scholarship (Grant ID: GOIPG/2016/551) & the Frank Jeal Scholarship, both awarded to GD.
Keywords:	Liver; Migration; Immunotolerance; Ascaris; Schistosoma; Plasmodium;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	13514
Identification Number:	https://doi.org/10.1186/s13071-019-3791-2
Depositing User:	James Carolan
Date Deposited:	09 Nov 2020 15:38
Journal or Publication Title:	Parasites & Vectors
Publisher:	BMC
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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