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    Preferential Selection of IMP and VIM Metallo-β-Lactamases by Imipenem in Pseudomonas aeruginosa


    Walsh, Fiona and Bracher, S. and Turner, P. and Amyes, Sebastian G.B. (2007) Preferential Selection of IMP and VIM Metallo-β-Lactamases by Imipenem in Pseudomonas aeruginosa. Experimental Chemotherapy, 53. pp. 407-409. ISSN 0536–0407

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    Abstract

    Mixed populations of Pseudomonas aeruginosa, comprising a carbapenem-susceptible and a carbapenem-resistant strain, containing either the IMP or VIM -lactamases, were exposed to imipenem. They developed resistance to both imipenem and meropenem. When the same mixed populations were exposed to meropenem, only the mixture containing the VIM -lactamases became resistant to both carbapenems.

    Item Type: Article
    Keywords: Competition studies Carbapenems; Metallo-β-lactamase;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 13553
    Identification Number: https://doi.org/10.1159/000109815
    Depositing User: Fiona Walsh
    Date Deposited: 09 Nov 2020 16:54
    Journal or Publication Title: Experimental Chemotherapy
    Publisher: Karger
    Refereed: Yes
    URI:

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