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    Targeting adhesion in fungal pathogen Candida albicans


    Martin, Harlei and Kavanagh, Kevin and Velasco-Torrijos, Trinidad (2020) Targeting adhesion in fungal pathogen Candida albicans. Future Medicinal Chemistry. ISSN 1756-8927

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    Abstract

    Fungal infections with increasing resistance to conventional therapies are a growing concern. Candida albicans is a major opportunistic yeast responsible for mucosal and invasive infections. Targeting the initial step of the infection process (i.e., C. albicans adhesion to the host cell) is a promising strategy. A wide variety of molecules can interfere with adhesion processes via an assortment of mechanisms. Herein, we focus on how small molecules disrupt biosynthesis of fungal cell wall components and membrane structure, prevent the localization of GPI-anchor proteins, inhibit production of enzymes involved in adhesion, downregulate genes encoding adhesins and competitively inhibit receptor interactions. As a result, adhesion of C. albicans to host cells is reduced, paving the way to new classes of antifungal agents.

    Item Type: Article
    Additional Information: Epub ahead of print: Cite as: Targeting adhesion in fungal pathogen Candida albicans Harlei Martin, Kevin Kavanagh, and Trinidad Velasco-Torrijos Future Medicinal Chemistry 0 0:0. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0
    Keywords: adhesion inhibitors; anti-adhesion therapies; antifungal agents; antimicrobial resistance; Candida albicans; virulence factors;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Faculty of Science and Engineering > Chemistry
    Item ID: 13671
    Identification Number: https://doi.org/10.4155/fmc-2020-0052
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 26 Nov 2020 15:16
    Journal or Publication Title: Future Medicinal Chemistry
    Publisher: Future Science
    Refereed: Yes
    URI:

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