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    TLR3 in antiviral immunity: key player or bystander?

    Schroeder, Martina and Bowie, Andrew G. (2005) TLR3 in antiviral immunity: key player or bystander? Trends in Immunology, 26 (9). pp. 462-468. ISSN 1471-4906

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    Toll-like receptor 3 (TLR3), which recognizes double-stranded (ds)RNA, was the first identified antiviral TLR and, because dsRNA is a universal viral molecular pattern, TLR3 has been assumed to have a central role in the host response to viruses. However, this role has recently been questioned by in vivo studies and the discovery of several other antiviral pattern-recognition receptors. In this review, the function of TLR3 in the context of these other receptors, namely TLR7, 8 and 9 and the newly identified dsRNA-receptor retinoic-acid inducible gene-I (RIG-I) is discussed. Also, recent research concerning the expression profile of TLR3, its evasion by viruses and a potential role in crosspriming is addressed, which reveals a clearer appreciation of the contribution of TLR3 to antiviral immunity.

    Item Type: Article
    Additional Information: Cite as: Martina Schröder, Andrew G. Bowie, TLR3 in antiviral immunity: key player or bystander?, Trends in Immunology, Volume 26, Issue 9, 2005, Pages 462-468, ISSN 1471-4906, Funding: Work in our laboratory is supported by Science Foundation Ireland, The Health Research Board and the Irish Research Council for Science, Education and Technology (IRCSET).
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 13679
    Identification Number:
    Depositing User: Martina Schroeder
    Date Deposited: 27 Nov 2020 16:04
    Journal or Publication Title: Trends in Immunology
    Publisher: Elsevier
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Irish Research Council for Science, Education and Technology (IRCSET)
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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