Harmon, Cathal and O'Farrelly, Cliona and Robinson, Mark W. (2020) The Immune Consequences of Lactate in the Tumor Microenvironment. In: Tumor Microenvironment. Advances in Experimental Medicine and Biology book series: AEMB (1259). Springer, Cham, Switzerland, pp. 113-124. ISBN 9783030430931 (Submitted)

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Abstract

The tumor microenvironment consists of complex and dynamic networks of cytokines, growth factors, and metabolic products. These contribute to significant alterations in tissue architecture, cell growth, immune cell phenotype, and function. Increased glycolytic flux is commonly observed in solid tumors and is associated with significant changes in metabolites, generating high levels of lactate. While elevated glycolytic flux is a characteristic metabolic adaption of tumor cells, glycolysis is also a key metabolic program utilized by a variety of inflammatory immune cells. As such lactate and the pH changes associated with lactate transport affect not only tumor cells but also immune cells. Here we provide an overview of lactate metabolic pathways and the effects lactate has on tumor growth and immune cell function. This knowledge provides opportunities for synergistic therapeutic approaches that combine metabolic drugs, which limit tumor growth and support immune cell function, together with immunotherapies to enhance tumor eradication.

Item Type:	Book Section
Additional Information:	This is the preprint version of the published chapter, which is available at Harmon C., O’Farrelly C., Robinson M.W. (2020) The Immune Consequences of Lactate in the Tumor Microenvironment. In: Birbrair A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1259. Springer, Cham. https://doi.org/10.1007/978-3-030-43093-1_7
Keywords:	Lactate; lactic acid; pH; tumor microenvironment; anti-tumor immunity; metabolism; glycolysis; immunotherapy; biosynthesis; Warburg; NK cells; T cells; macrophages; MCT; metabolic therapies;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	13789
Identification Number:	https://doi.org/10.1007/978-3-030-43093-1_7
Depositing User:	Mark Robinson
Date Deposited:	12 Jan 2021 15:40
Journal or Publication Title:	Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1259.
Publisher:	Springer
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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