Pärnänen, Katariina M. M. and Narciso-da-Rocha, Carlos and Kneis, David and Berendonk, Thomas U. and Cacace, Damlano and Thuy Do, Thi and Elpers, Christian and Fatta-Kassinos, Despo and Henriques, Isabel and Jaeger, Thomas and Karkman, Antti and Martinez, Jose Luis and Michael, Stella G and Michael-Kordatou, Irene and O'Sullivan, Kristin and Rodriguez-Mozaz, Sara and Schwartz, Thomas and Sheng, Hongjie and Sørum, Henning and Stedtfeld, Robert D. and Tiedje, James M. and Giustina, Saulo Varela Della and Walsh, Fiona and Vaz-Moreira, Ivone and Virta, Marko and Manaia, Célia M. (2019) Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence. Science Advances, 5 (3). ISSN 2375-2548

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Abstract

Integrated antibiotic resistance (AR) surveillance is one of the objectives of the World Health Organization global action plan on antimicrobial resistance. Urban wastewater treatment plants (UWTPs) are among the most important receptors and sources of environmental AR. On the basis of the consistent observation of an increasing northto-south clinical AR prevalence in Europe, this study compared the influent and final effluent of 12 UWTPs located in seven countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway). Using highly parallel quantitative polymerase chain reaction, we analyzed 229 resistance genes and 25 mobile genetic elements. This first trans-Europe surveillance showed that UWTP AR profiles mirror the AR gradient observed in clinics. Antibiotic use, environmental temperature, and UWTP size were important factors related with resistance persistence and spread in the environment. These results highlight the need to implement regular surveillance and control measures, which may need to be appropriate for the geographic regions.

Item Type:	Article
Keywords:	Antibiotic resistance; European wastewater treatment plants; mirrors; pattern; clinical antibiotic resistance prevalence;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	13843
Identification Number:	https://doi.org/10.1126/sciadv.aau9124
Depositing User:	Fiona Walsh
Date Deposited:	19 Jan 2021 12:21
Journal or Publication Title:	Science Advances
Publisher:	American Association for the Advancement of Science
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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