Ahmed, Muhib and Rooney, A. Denise and McCann, Malachy and Devereux, Michael and Twamley, Brendan and Milesi Galdino, Anna Clara and Sangenito, Leandro Stefano and Souza, Lucieri Olegario Pereira and Lourenco, Maria Cristina and Gomes, Karen and Santos, Andre L. S. (2019) Synthesis and antimicrobial activity of a phenanthroline-isoniazid hybrid ligand and its Ag+ and Mn2+ complexes. Biometals, 32 (4). pp. 671-682. ISSN 0966-0844

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Abstract

Hydrazide ligand, (Z)-N'-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag+ and Mn2+ complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)2]NO3, [Ag(1)2]BF4 and [Mn(1)2](NO3)2. Polymeric {[Ag(1)(NO3)]}n has 1:1 stoichiometry and forms upon infusion of CH2Cl2 into a DMSO solution of [Ag(1)2]NO3. {[Ag(1)(NO3)]}n was structurally characterized using X-ray crystallography. Metal-free 1 and its 1:2 complexes exhibit very good, broad-spectrum antimicrobial activity and are not excessively toxic to mammalian cells (A549 lineage).

Item Type:	Article
Keywords:	1,10-Phenanthroline; Anti-tuberculosis activity; Antibacterial activity; Antibiotic resistance; Metal complexes;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	13888
Identification Number:	https://doi.org/10.1007/s10534-019-00204-5
Depositing User:	Dr. Denise Rooney
Date Deposited:	01 Feb 2021 13:50
Journal or Publication Title:	Biometals
Publisher:	Springer Verlag
Refereed:	Yes
URI:	Publisher

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