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    Dysregulation of Natural Killer Cells in Obesity


    O'Shea, Donal and Hogan, Andrew (2019) Dysregulation of Natural Killer Cells in Obesity. Cancers, 11 (4). ISSN 2072-6694

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    Abstract

    Natural killer (NK) cells are a population of lymphocytes which classically form part of the innate immune system. They are defined as innate lymphocytes, due to their ability to kill infected or transformed cells without prior activation. In addition to their cytotoxic abilities, NK cells are also rapid producers of inflammatory cytokines such as interferon gamma (IFN-γ) and are therefore a critical component of early immune responses. Due to these unique abilities, NK cells are a very important component of host protection, especially anti-tumour and anti-viral immunity. Obesity is a worldwide epidemic, with over 600 million adults and 124 million children now classified as obese. It is well established that individuals who are obese are at a higher risk of many acute and chronic conditions, including cancer and viral infections. Over the past 10 years, many studies have investigated the impact of obesity on NK cell biology, detailing systemic dysregulation of NK cell functions. More recently, several studies have investigated the role of NK cells in the homeostasis of adipose tissue and the pathophysiology of obesity. In this review, we will discuss in detail these studies and focus on emerging data detailing the metabolic mechanisms altering NK cells in obesity.

    Item Type: Article
    Additional Information: Funding: A.E.H. is supported by research grants from the National Children’s Research Centre Ireland. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Cite as: O’Shea, D.; Hogan, A.E. Dysregulation of Natural Killer Cells in Obesity. Cancers 2019, 11, 573. https://doi.org/10.3390/cancers11040573
    Keywords: cancer; NK cell; obesity; metabolism; adipose tissue;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 13973
    Identification Number: https://doi.org/10.3390/cancers11040573
    Depositing User: Andrew Hogan
    Date Deposited: 08 Feb 2021 16:55
    Journal or Publication Title: Cancers
    Publisher: MDPI
    Refereed: Yes
    Funders: National Children’s Research Centre Ireland
    URI:

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