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    Synthesis of Novel Benzimidazolium Gemini Surfactants and Evaluation of Their Anti-Candida Activity


    Wani, Farooq Ahmad and Amaduddin, - and Aneja, Babita and Sheehan, Gerard and Kavanagh, Kevin and Ahmad, Rabia and Abid, Mohammad and Patel, Rajan (2019) Synthesis of Novel Benzimidazolium Gemini Surfactants and Evaluation of Their Anti-Candida Activity. ACS Omega, 4 (7). pp. 11871-11879. ISSN 2470-1343

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    Abstract

    Owing to the rise in antimicrobial and chemotherapeutic drug resistance, there is a desperate need to formulate newer as well as more effective agents. With this perspective, here we outline the synthesis of two novel gemini surfactants with different substitutions at the nitrogen atom of the benzimidazolium ring. Both the compounds induced significant reductions in Candida growth in various yeast strains. The reduction in Candida growth seemed likely through the reduction in ergosterol biosynthesis: a sterol constituent of yeast cell membranes. Different concentrations of both compounds were used to determine the cellular ergosterol content which indicates an important disordering of the ergosterol biosynthetic pathway. Cytotoxic studies were carried out using HEK 293 (human embryonic-kidney cells) and Galleria mellonella larvae (an in vivo model of antimicrobial studies). Administration of both the compounds to G. mellonella larvae diseased by the yeast Candida albicans resulted in increased survival indicating their in vivo activity.

    Item Type: Article
    Additional Information: Cite as: ynthesis of Novel Benzimidazolium Gemini Surfactants and Evaluation of Their Anti-Candida Activity Farooq Ahmad Wani, Amaduddin, Babita Aneja, Gerard Sheehan, Kevin Kavanagh, Rabia Ahmad, Mohammad Abid, and Rajan Patel ACS Omega 2019 4 (7), 11871-11879 DOI: 10.1021/acsomega.9b01056
    Keywords: Synthesis; Novel; Benzimidazolium; Gemini; Surfactants; Evaluation; Anti-Candida; Activity;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 14157
    Identification Number: https://doi.org/10.1021/acsomega.9b01056
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 10 Mar 2021 15:11
    Journal or Publication Title: ACS Omega
    Publisher: American Chemical Society
    Refereed: Yes
    URI:

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