Wani, Farooq Ahmad and Amaduddin, - and Aneja, Babita and Sheehan, Gerard and Kavanagh, Kevin and Ahmad, Rabia and Abid, Mohammad and Patel, Rajan
(2019)
Synthesis of Novel Benzimidazolium Gemini Surfactants and Evaluation of Their Anti-Candida Activity.
ACS Omega, 4 (7).
pp. 11871-11879.
ISSN 2470-1343
Abstract
Owing to the rise in antimicrobial and
chemotherapeutic drug resistance, there is a desperate need
to formulate newer as well as more effective agents. With this
perspective, here we outline the synthesis of two novel gemini
surfactants with different substitutions at the nitrogen atom of
the benzimidazolium ring. Both the compounds induced
significant reductions in Candida growth in various yeast
strains. The reduction in Candida growth seemed likely
through the reduction in ergosterol biosynthesis: a sterol
constituent of yeast cell membranes. Different concentrations
of both compounds were used to determine the cellular
ergosterol content which indicates an important disordering of
the ergosterol biosynthetic pathway. Cytotoxic studies were
carried out using HEK 293 (human embryonic-kidney cells) and Galleria mellonella larvae (an in vivo model of antimicrobial
studies). Administration of both the compounds to G. mellonella larvae diseased by the yeast Candida albicans resulted in
increased survival indicating their in vivo activity.
Item Type: |
Article
|
Additional Information: |
Cite as: ynthesis of Novel Benzimidazolium Gemini Surfactants and Evaluation of Their Anti-Candida Activity
Farooq Ahmad Wani, Amaduddin, Babita Aneja, Gerard Sheehan, Kevin Kavanagh, Rabia Ahmad, Mohammad Abid, and Rajan Patel
ACS Omega 2019 4 (7), 11871-11879
DOI: 10.1021/acsomega.9b01056 |
Keywords: |
Synthesis; Novel; Benzimidazolium; Gemini; Surfactants; Evaluation; Anti-Candida; Activity; |
Academic Unit: |
Faculty of Science and Engineering > Biology |
Item ID: |
14157 |
Identification Number: |
https://doi.org/10.1021/acsomega.9b01056 |
Depositing User: |
Dr. Kevin Kavanagh
|
Date Deposited: |
10 Mar 2021 15:11 |
Journal or Publication Title: |
ACS Omega |
Publisher: |
American Chemical Society |
Refereed: |
Yes |
URI: |
|
Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
Repository Staff Only(login required)
|
Item control page |
Downloads per month over past year
Origin of downloads