The ability to conduct in-situ real-time process-structure-property checks has the potential to overcome process and material uncertainties, which are key obstacles to improved uptake of metal powder bed fusion in industry. Efforts are underway for live process monitoring such as thermal and image-based data gathering for every layer printed. Current crystal plasticity finite element (CPFE) modelling is cap- able of predicting the associated strength based on a microstructural image and material data but is com- putationally expensive. This work utilizes a large database of input–output samples from CPFE modelling to develop a trained deep neural network (DNN) model which instantly estimates the output (strength prediction) associated with a given input (microstructure) of multi-phase additive manufactured stain- less steels. The DNN model successfully recognizes phase regions and the associated unique crystallo- graphic orientation variations. It also captures differences in macroscopic stress response due to the varying microstructure. However, it is less reliable in terms of fatigue life predictions.