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    Mucosal Associated Invariant T Cells in Cancer-Friend or Foe?


    O’Neill, Chloe and Cassidy, Féaron C. and O’Shea, Donal and Hogan, Andrew E. (2021) Mucosal Associated Invariant T Cells in Cancer-Friend or Foe? Cancers, 13 (1582). pp. 1-11. ISSN 2072-6694

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    Abstract

    Mucosal associated invariant T (MAIT) cells are a population of unconventional T cells which can bridge the innate and adaptive immune systems. Well-described roles for MAIT cells include host protection against invading bacteria, fungi and viruses. Upon activation, MAIT cells become prolific effector cells, capable of producing a range of cytokines and lytic molecules. In addition to their anti-microbial role, MAIT cells have been implicated in immune responses to cancer, with opposing beneficial and pathogenic roles reported. On the one hand, MAIT cells can home to the site of the tumour in many human cancers and can produce anti-tumour molecules. On the other, MAIT cells can display defective phenotypes in certain cancers and produce pro-tumour molecules. In this review, we discuss the current literature on the diverse roles for MAIT cells in cancer, outlining their frequencies, functions and associations with N staging and prognosis. We also discuss potential mechanisms underpinning cancer-related alterations in MAIT cells and highlight therapeutic approaches to harness or target MAIT cells in cancer.

    Item Type: Article
    Keywords: MAIT cells; cancer; immune checkpoint; metabolism;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 16177
    Identification Number: https://doi.org/10.3390/cancers13071582
    Depositing User: Andrew Hogan
    Date Deposited: 22 Jun 2022 11:38
    Journal or Publication Title: Cancers
    Publisher: MDPI
    Refereed: Yes
    URI:

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