Rolandsson Enes, Sara and Krasnodembskaya, Anna D. and English, Karen and Dos Santos, Claudia C. and Weiss, Daniel J. (2021) Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases. Frontiers in Pharmacology, 12. pp. 1-8. ISSN 1663-9812

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Abstract

Recent advances in cell based therapies for lung diseases and critical illnesses offer significant promise. Despite encouraging preclinical results, the translation of efficacy to the clinical settings have not been successful. One of the possible reasons for this is the lack of understanding of the complex interaction between mesenchymal stromal cells (MSCs) and the host environment. Other challenges for MSC cell therapies include cell sources, dosing, disease target, donor variability, and cell product manufacturing. Here we provide an overview on advances and current issues with a focus on MSC-based cell therapies for inflammatory acute respiratory distress syndrome varieties and other inflammatory lung diseases.

Item Type:	Article
Keywords:	cell therapy; mesenchymal stromal cells (MSCs); mscs; lung diseases; respiratory diseases and disorders;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	16212
Identification Number:	https://doi.org/10.3389/fphar.2021.647652
Depositing User:	Karen English
Date Deposited:	29 Jun 2022 10:35
Journal or Publication Title:	Frontiers in Pharmacology
Publisher:	Frontiers Media
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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