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Rolandsson Enes, Sara, Krasnodembskaya, Anna D., English, Karen, Dos Santos, Claudia C. and Weiss, Daniel J. (2021) Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases. Frontiers in Pharmacology, 12. pp. 1-8. ISSN 1663-9812
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Abstract
Recent advances in cell based therapies for lung diseases and critical illnesses offer
significant promise. Despite encouraging preclinical results, the translation of efficacy to the
clinical settings have not been successful. One of the possible reasons for this is the lack of
understanding of the complex interaction between mesenchymal stromal cells (MSCs) and
the host environment. Other challenges for MSC cell therapies include cell sources, dosing,
disease target, donor variability, and cell product manufacturing. Here we provide an
overview on advances and current issues with a focus on MSC-based cell therapies for
inflammatory acute respiratory distress syndrome varieties and other inflammatory lung
diseases.
| Item Type: | Article |
|---|---|
| Keywords: | cell therapy; mesenchymal stromal cells (MSCs); mscs; lung diseases; respiratory diseases and disorders; |
| Academic Unit: | Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute |
| Item ID: | 16212 |
| Identification Number: | 10.3389/fphar.2021.647652 |
| Depositing User: | Karen English |
| Date Deposited: | 29 Jun 2022 10:35 |
| Journal or Publication Title: | Frontiers in Pharmacology |
| Publisher: | Frontiers Media |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/16212 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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