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    Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases


    Rolandsson Enes, Sara and Krasnodembskaya, Anna D. and English, Karen and Dos Santos, Claudia C. and Weiss, Daniel J. (2021) Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases. Frontiers in Pharmacology, 12. pp. 1-8. ISSN 1663-9812

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    Abstract

    Recent advances in cell based therapies for lung diseases and critical illnesses offer significant promise. Despite encouraging preclinical results, the translation of efficacy to the clinical settings have not been successful. One of the possible reasons for this is the lack of understanding of the complex interaction between mesenchymal stromal cells (MSCs) and the host environment. Other challenges for MSC cell therapies include cell sources, dosing, disease target, donor variability, and cell product manufacturing. Here we provide an overview on advances and current issues with a focus on MSC-based cell therapies for inflammatory acute respiratory distress syndrome varieties and other inflammatory lung diseases.

    Item Type: Article
    Keywords: cell therapy; mesenchymal stromal cells (MSCs); mscs; lung diseases; respiratory diseases and disorders;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 16212
    Identification Number: https://doi.org/10.3389/fphar.2021.647652
    Depositing User: Karen English
    Date Deposited: 29 Jun 2022 10:35
    Journal or Publication Title: Frontiers in Pharmacology
    Publisher: Frontiers Media
    Refereed: Yes
    URI:

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