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    Comprehensive Review: Immunogenicity of Adult Mesenchymal Stem Cells: Lessons from the Fetal Allograft

    Barry, Frank P. and Murphy, J. Mary and English, Karen and Mahon, Bernard P. (2005) Comprehensive Review: Immunogenicity of Adult Mesenchymal Stem Cells: Lessons from the Fetal Allograft. Stem Cells and Development, 14 (3). pp. 252-265. ISSN 1547-3287

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    Herein we review recent data that support host tolerance of allogeneic adult mesenchymal stem cells (MSC). Evidence is emerging that donor MSC deploy a very powerful array of mechanisms that allow escape from host allogeneic responses. These mechanisms include limited expression of alloantigen by the stem cell and cell contact-dependent and -independent mechanisms. MSC modulate host dendritic cell and T cell function, promoting induction of suppressor or regulatory T cells. These effects are complemented by the induction of divisional arrest anergy in T cells and by stem cell production of soluble immunomodulatory factors, including interleukin-10, transforming growth factor–β, prostaglandin E2, and hepatocyte growth factor. In addition, MSC express the enzyme indoleamine 2,3-dioxygenase, which creates a tryptophan-depleted milieu that promotes immunosuppression. We propose that these observations show striking similarity to emerging data on the maternal acceptance of the fetal allograft. This comparison suggests new approaches to determine the contribution of different mechanisms to the successful use of MSC in regenerative medicine.

    Item Type: Article
    Keywords: Comprehensive Review; Immunogenicity; Adult Mesenchymal Stem Cells; Lessons; Fetal Allograft;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 16214
    Identification Number:
    Depositing User: Karen English
    Date Deposited: 29 Jun 2022 11:06
    Journal or Publication Title: Stem Cells and Development
    Publisher: Mary Ann Liebert
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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