Judge, Eoin P. and Hughes, J. M. Lynne and Egan, Jim J. and Maguire, Michael and Molloy, Emer L. and O'Dea, Shirley (2014) Anatomy and Bronchoscopy of the Porcine Lung. A Model for Translational Respiratory Medicine. American Journal of Respiratory Cell and Molecular Biology, 51 (3). pp. 334-343. ISSN 1535-4989

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Abstract

The porcine model has contributed significantly to biomedical research over many decades. The similar size and anatomy of pig and human organs make this model particularly beneficial for translational research in areas such as medical device development, therapeutics and xenotransplantation. In recent years, a major limitation with the porcine model was overcome with the successful generation of gene-targeted pigs and the publication of the pig genome. As a result, the role of this model is likely to become even more important. For the respiratory medicine field, the similarities between pig and human lungs give the porcine model particular potential for advancing translational medicine. An increasing number of lung conditions are being studied and modeled in the pig. Genetically modified porcine models of cystic fibrosis have been generated that, unlike mouse models, develop lung disease similar to human cystic fibrosis. However, the scientific literature relating specifically to porcine lung anatomy and airway histology is limited and is largely restricted to veterinary literature and textbooks. Furthermore, methods for in vivo lung procedures in the pig are rarely described. The aims of this review are to collate the disparate literature on porcine lung anatomy, histology, and microbiology; to provide a comparison with the human lung; and to describe appropriate bronchoscopy procedures for the pig lungs to aid clinical researchers working in the area of translational respiratory medicine using the porcine model.

Item Type:	Article
Keywords:	porcine; bronchoscopy; respiratory; translational; lung;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	16289
Identification Number:	https://doi.org/10.1165/rcmb.2013-0453TR
Depositing User:	Dr. Shirley O'Dea
Date Deposited:	12 Jul 2022 12:09
Journal or Publication Title:	American Journal of Respiratory Cell and Molecular Biology
Publisher:	American Thoracic Society
Refereed:	Yes
URI:	http://www.ajrcmb.org/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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