Taurines, Regina and Dudley, Edward and Grassl, Julia and Warnke, Andreas and Gerlach, Manfred and Coogan, Andrew and Thome, Johannes (2011) Proteomic research in psychiatry. Journal of Psychopharmacology, 25 (2). pp. 151-196. ISSN 0269-8811

Preview

Download (602kB) | Preview

Abstract

Psychiatric disorders such as Alzheimer's disease, schizophrenia and mood disorders are severe and disabling conditions of largely unknown origin and poorly understood pathophysiology. An accurate diagnosis and treatment of these disorders is often complicated by their aetiological and clinical heterogeneity. In recent years proteomic technologies based on mass spectrometry have been increasingly used, especially in the search for diagnostic and prognostic biomarkers in neuropsychiatric disorders. Proteomics enable an automated high-throughput protein determination revealing expression levels, post-translational modifications and complex protein-interaction networks. In contrast to other methods such as molecular genetics, proteomics provide the opportunity to determine modifications at the protein level thereby possibly being more closely related to pathophysiological processes underlying the clinical phenomenology of specific psychiatric conditions. In this article we review the theoretical background of proteomics and its most commonly utilized techniques. Furthermore the current impact of proteomic research on diverse psychiatric diseases, such as Alzheimer's disease, schizophrenia, mood and anxiety disorders, drug abuse and autism, is discussed. Proteomic methods are expected to gain crucial significance in psychiatric research and neuropharmacology over the coming decade.

Item Type:	Article
Keywords:	Alzheimer’s disease; anxiety disorders; autism; drug addiction; mood disorders; protein profiling; proteomics; psychiatry; schizophrenia;
Academic Unit:	Assisting Living & Learning,ALL institute Faculty of Science and Engineering > Psychology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	16457
Identification Number:	https://doi.org/10.1177/0269881109106931
Depositing User:	Dr. Andrew Coogan
Date Deposited:	30 Aug 2022 14:26
Journal or Publication Title:	Journal of Psychopharmacology
Publisher:	SAGE Publications
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads