Coogan, Andrew and Wyse, Cathy A. (2008) Neuroimmunology of the circadian clock. Brain Research, 1232. pp. 104-112. ISSN 0006-8993

Preview

Download (380kB) | Preview

Abstract

Circadian timekeeping is a ubiquitous feature of all eukaryotes which allows for the imposition of a biologically appropriate temporal architecture on an animal's physiology, behavior and metabolism. There is growing evidence that in mammals the processes of circadian timing are under the influence of the immune system. Such a role for the neuroimmune regulation of the circadian clock has inferences for phenomena such as sickness behavior. Conversely, there is also accumulating evidence for a circadian influence on immune function, raising the likelihood that there is a bidirectional communication between the circadian and immune systems. In this review, we examine the evidence for these interactions, including circadian rhythmicity in models of disease and immune challenge, distribution of cytokines and their receptors in the suprachiasmatic nucleus of the hypothalamus, the site of the master circadian pacemaker, and the evidence for endogenous circadian timekeeping in immune cells.

Item Type:	Article
Keywords:	Circadian; Cytokine; Neuroimmunology; SCN; Clock gene;
Academic Unit:	Assisting Living & Learning,ALL institute Faculty of Science and Engineering > Psychology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	16463
Identification Number:	https://doi.org/10.1016/j.brainres.2008.07.087
Depositing User:	Dr. Andrew Coogan
Date Deposited:	30 Aug 2022 15:07
Journal or Publication Title:	Brain Research
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads