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    Neuroimmunology of the circadian clock

    Coogan, Andrew and Wyse, Cathy A. (2008) Neuroimmunology of the circadian clock. Brain Research, 1232. pp. 104-112. ISSN 0006-8993

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    Circadian timekeeping is a ubiquitous feature of all eukaryotes which allows for the imposition of a biologically appropriate temporal architecture on an animal's physiology, behavior and metabolism. There is growing evidence that in mammals the processes of circadian timing are under the influence of the immune system. Such a role for the neuroimmune regulation of the circadian clock has inferences for phenomena such as sickness behavior. Conversely, there is also accumulating evidence for a circadian influence on immune function, raising the likelihood that there is a bidirectional communication between the circadian and immune systems. In this review, we examine the evidence for these interactions, including circadian rhythmicity in models of disease and immune challenge, distribution of cytokines and their receptors in the suprachiasmatic nucleus of the hypothalamus, the site of the master circadian pacemaker, and the evidence for endogenous circadian timekeeping in immune cells.

    Item Type: Article
    Keywords: Circadian; Cytokine; Neuroimmunology; SCN; Clock gene;
    Academic Unit: Assisting Living & Learning,ALL institute
    Faculty of Science and Engineering > Psychology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 16463
    Identification Number:
    Depositing User: Dr. Andrew Coogan
    Date Deposited: 30 Aug 2022 15:07
    Journal or Publication Title: Brain Research
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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