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    Circadian and Photic Regulation of Phosphorylation of ERK1/2 and Elk-1 in the Suprachiasmatic Nuclei of the Syrian Hamster

    Coogan, Andrew and Piggins, Hugh D. (2003) Circadian and Photic Regulation of Phosphorylation of ERK1/2 and Elk-1 in the Suprachiasmatic Nuclei of the Syrian Hamster. The Journal of Neuroscience, 23 (7). pp. 3085-3093. ISSN 0270-6474

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    In this study we investigated the circadian and photic regulation of phosphorylation of the extracellular signal-related kinase (ERK) 1/2, and the transcription factor Elk-1 in the suprachiasmatic nuclei of the Syrian hamster. We report that levels of phosphorylated ERK (P-ERK) are rhythmic, peaking during the mid subjective day, whereas phosphorylated Elk-1 (P-Elk-1) shows no distinct rhythm. Light pulses during the subjective night rapidly, but transiently, induce P-ERK, whereas P-Elk-1 is also induced, albeit with a slower time course. Application of the ERK pathway inhibitor U0126 attenuates photic induction of both P-ERK and P-Elk-1 and phase advances of wheel-running behavior. The NMDA receptor channel blocker, MK-801, also significantly attenuates photic induction of P-ERK and P-Elk-1. Taken together, these results indicate a role of the ERK cascade in the regulation of free-running circadian rhythms and of photic-resetting of these rhythms and suggest that in the mammalian suprachiasmatic nuclei, Elk-1 represents a novel molecular component of the photic-induction pathway.

    Item Type: Article
    Keywords: circadian; MAP kinase; clocks; brain; phosphorylation; Elk-1;
    Academic Unit: Assisting Living & Learning,ALL institute
    Faculty of Science and Engineering > Psychology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 16468
    Identification Number:
    Depositing User: Dr. Andrew Coogan
    Date Deposited: 30 Aug 2022 16:00
    Journal or Publication Title: The Journal of Neuroscience
    Publisher: Society for Neuroscience
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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