Wyse, Cathy and O'Malley, Grace and Coogan, Andrew and McConkey, Sam and Smith, Daniel J. (2021) Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort. iScience, 24 (102255). pp. 1-28. ISSN 25890042

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Abstract

Seasonal disease outbreaks are perennial features of human infectious disease but the factors generating these patterns are unclear. Here we investigate seasonal and daytime variability in multiple immune parameters in 329,261 participants in UK Biobank and test for associations with a wide range of environmental and lifestyle factors, including changes in day length, outdoor temperature and vitamin D at the time the blood sample was collected. Seasonal patterns were evident in lymphocyte and neutrophil counts, and C-reactive protein CRP, but not monocytes, and these were independent of lifestyle, demographic, and environmental factors. All the immune parameters assessed demonstrated significant daytime variation that was independent of confounding factors. At a population level, human immune parameters vary across season and across time of day, independent of multiple confounding factors. Both season and time of day are fundamental dimensions of immune function that should be considered in all studies of immuno-prophylaxis and disease transmission.

Item Type:	Article
Keywords:	Seasonal; daytime; variation; multiple immune parameters; humans; Evidence; participants; UK Biobank cohort;
Academic Unit:	Assisting Living & Learning,ALL institute Faculty of Science and Engineering > Psychology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	16609
Identification Number:	https://doi.org/10.1016/j.isci.2021.102255
Depositing User:	Dr. Andrew Coogan
Date Deposited:	10 Oct 2022 15:45
Journal or Publication Title:	iScience
Publisher:	CellPress
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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