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    The Role of the Circadian System in Attention Deficit Hyperactivity Disorder

    Bondopadhyay, Upasana and Díaz-Orueta, Unai and Coogan, Andrew (2021) The Role of the Circadian System in Attention Deficit Hyperactivity Disorder. Advances in Experimental Medicine and Biology 1344, 1344. pp. 113-127. ISSN 0065-2598

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    Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental condition characterised by the core symptoms of inattention, impulsivity and hyperactivity. Similar to many other neuropsychiatric conditions, ADHD is associated with very high levels of sleep disturbance. However, it is not clear whether such sleep disturbances are precursors to, or symptoms of, ADHD. Neither is it clear through which mechanisms sleep and ADHD are linked. One possible link is via modulation of circadian rhythms. In this chapter we overview the evidence that ADHD is associated with alterations in circadian processes, manifesting as later chronotype and delayed sleep phase in ADHD, and examine some mechanisms that may lead to such changes. We also interrogate how the circadian clock may be a substrate for therapeutic intervention in ADHD (chronotherapy) and highlight important new questions to be addressed to move the field forward.

    Item Type: Article
    Additional Information: Cite as: Bondopadhyay, U., Diaz-Orueta, U. and Coogan, A.N., 2021. The role of the circadian system in attention deficit hyperactivity disorder. Circadian Clock in Brain Health and Disease, pp.113-127.
    Keywords: ADHD;
    Academic Unit: Assisting Living & Learning,ALL institute
    Faculty of Science and Engineering > Psychology
    Item ID: 16793
    Identification Number:
    Depositing User: Unai Diaz-Orueta
    Date Deposited: 20 Dec 2022 15:35
    Journal or Publication Title: Advances in Experimental Medicine and Biology 1344
    Refereed: Yes
      Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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