Faltraco, Frank and Palm, Denise and Coogan, Andrew and Uzoni, Adriana and Duwe, Isabell and Simon, Frederick and Tucha, Oliver and Thome, Johannes (2021) Remdesivir shifts circadian rhythmicity to eveningness; similar to the most prevalent chronotype in ADHD. Journal of Neural Transmission, 128 (7). pp. 1159-1168. ISSN 0300-9564

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Abstract

Circadian clocks control immunity and virus replication, as well as pharmacokinetics and efficacy therapeutics. The aim of this study was to investigate the extent of these relationships by measuring circadian gene expression in primary human-derived dermal fibroblast cultures (HDF) after remdesivir exposure. In the current study, we analysed circadian gene expression in a cohort of participants without a neuropsychiatric diagnosis. After ex vivo exposure to remdesivir to human dermal fibroblast (HDF) cultures and dexamethasone synchronization, the rhythmicity of circadian gene expression (Clock, Bmal1, Per1-3, Cry1) was analysed via qRT-PCR. In this study, D-MEQ scores indicated that participants without a neuropsychiatric diagnosis had no evening preference. Remdesivir leads to a slight phase-shift in Clock, Per1 and Per2. Significant different expressions of Bmal1 and Per3 were detected after remdesivir exposure: Bmal1 at ZT8 (t(22)=3.26, p=0.004), ZT24 (t(22)=− 2.66, p=0.015), ZT28 (t(20)=− 2.14, p=0.045) and Per3 at ZT8 (t(22)=− 4.27, p<0.001) and ZT12 (t(22)=− 2.61, p=0.016). A significant difference between chronotype and circadian gene expression for Bmal1, Cry1 and Per3 was observed. The present study shows that remdesivir has an impact on circadian function. It is well known that the circadian rhythm effects sleep and, moreover, sleep quality. The results suggest that remdesivir medication may alter sleep quality in participants without a neuropsychiatric diagnosis and shifts chronotype to evenness; similar as prevalent in ADHD

Item Type:	Article
Additional Information:	Cite as: Faltraco, F., Palm, D., Coogan, A. et al. Remdesivir shifts circadian rhythmicity to eveningness; similar to the most prevalent chronotype in ADHD. J Neural Transm 128, 1159–1168 (2021). https://doi.org/10.1007/s00702-021-02375-3
Keywords:	Remdesivir; Human dermal fibroblasts; Circadian rhythm;
Academic Unit:	Assisting Living & Learning,ALL institute Faculty of Science and Engineering > Psychology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	16918
Identification Number:	https://doi.org/10.1007/s00702-021-02375-3
Depositing User:	Dr. Andrew Coogan
Date Deposited:	07 Feb 2023 12:18
Journal or Publication Title:	Journal of Neural Transmission
Publisher:	Springer link
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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