Petersen, Celine and Sørensen, Trine and Nielsen, Mikkel R. and Sondergaard, Teis E. and Sørensen, Jens L. and Fitzpatrick, David A. and Frisvad, Jens C. and Nielsen, Kåre L. (2023) Comparative genomic study of the Penicillium genus elucidates a diverse pangenome and 15 lateral gene transfer events. IMA Fungus, 14 (3). pp. 1-17. ISSN 2210-6359

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Abstract

The Penicillia are known to produce a wide range natural products—some with devastating outcome for the agricultural industry and others with unexploited potential in different applications. However, a large-scale overview of the biosynthetic potential of different species has been lacking. In this study, we sequenced 93 Penicillium isolates and, together with eleven published genomes that hold similar assembly characteristics, we established a species phylogeny as well as defining a Penicillium pangenome. A total of 5612 genes were shared between≥98 isolates corresponding to approximately half of the average number of genes a Penicillium genome holds. We further identified 15 lateral gene transfer events that have occurred in this collection of Penicillium isolates, which might have played an important role, such as niche adaption, in the evolution of these fungi. The comprehensive characterization of the genomic diversity in the Penicillium genus supersedes single-reference genomes, which do not necessarily capture the entire genetic variation.

Item Type:	Article
Keywords:	Long read sequencing; MinION; Filamentous fungi; Penicillium; Phylogenetics; Pangenome; Lateral gene transfer; Mycotoxins;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17086
Identification Number:	https://doi.org/10.1186/s43008-023-00108-7
Depositing User:	David Fitzpatrick
Date Deposited:	03 Apr 2023 13:54
Journal or Publication Title:	IMA Fungus
Publisher:	International Mycological Association
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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