Evangelou, Evangelos and Warren, Helen R. and Mosen-Ansorena, David and Mifsud, Borbala and Pazoki, Raha and Gao, He and Ntritsos, Georgios and Dimou, Niki and Cabrera, Claudia P. and Karaman, Ibrahim and Ng, Fu Liang and Evangelou, Marina and Witkowska, Katarzyna and Tzanis, Evan and Hellwege, Jacklyn N. and Giri, Ayush and Velez Edwards, Digna R. and Sun, Yan V. and Cho, Kelly and Gaziano, J. Michael and Wilson, Peter W. F. and Tsao, Philip S. and Kovesdy, Csaba P. and Esko, Tonu and Mägi, Reedik and Milani, Lili and Almgren, Peter and Boutin, Thibaud and Debette, Stéphanie and Ding, Jun and Giulianini, Franco and Holliday, Elizabeth G. and Jackson, Anne U. and Li-Gao, Ruifang and Lin, Wei-Yu and Luan, Jian’an and Mangino, Massimo and Oldmeadow, Christopher and Prins, Bram Peter and Qian, Yong and Sargurupremraj, Muralidharan and Shah, Nabi and Surendran, Praveen and Thériault, Sébastien and Verweij, Niek and Willems, Sara M. and Zhao, Jing-Hua and Amouyel, Philippe and Connell, John and de Mutsert, Renée and Doney, Alex S. F. and Farrall, Martin and Menni, Cristina and Morris, Andrew D. and Noordam, Raymond and Paré, Guillaume and Poulter, Neil R. and Shields, Denis C. and Stanton, Alice and Thom, Simon and Abecasis, Gonçalo and Amin, Najaf and Arking, Dan E. and Ayers, Kristin L. and Barbieri, Caterina M. and Batini, Chiara and Bis, Joshua C. and Blake, Tineka and Bochud, Murielle and Boehnke, Michael and Boerwinkle, Eric and Boomsma, Dorret I. and Bottinger, Erwin P. and Braund, Peter S. and Brumat, Marco and Campbell, Archie and Campbell, Harry and Chakravarti, Aravinda and Chambers, John C. and Chauhan, Ganesh and Ciullo, Marina and Cocca, Massimiliano and Collins, Francis and Cordell, Heather J. and Davies, Gail and de Borst, Martin H. and de Geus, Eco J. and Deary, Ian J. and Deelen, Joris and Del Greco M., Fabiola and Demirkale, Cumhur Yusuf and Dörr, Marcus and Ehret, Georg B. and Elosua, Roberto and Enroth, Stefan and Erzurumluoglu, A. Mesut and Ferreira, Teresa and Frånberg, Mattias and Franco, Oscar H. and Gandin, Ilaria and Gasparini, Paolo and Giedraitis, Vilmantas and Gieger, Christian and Girotto, Giorgia and Goel, Anuj and Gow, Alan J. and Gudnason, Vilmundur and Guo, Xiuqing and Gyllensten, Ulf and Hamsten, Anders and Harris, Tamara B. and Harris, Sarah E. and Hartman, Catharina A. and Havulinna, Aki S. and Hicks, Andrew A. and Hofer, Edith and Hofman, Albert and Hottenga, Jouke-Jan and Huffman, Jennifer E. and Hwang, Shih-Jen and Ingelsson, Erik and James, Alan and Jansen, Rick and Jarvelin, Marjo-Riitta and Joehanes, Roby and Johansson, Åsa and Johnson, Andrew D. and Joshi, Peter K. and Jousilahti, Pekka and Jukema, J. Wouter and Jula, Antti and Kähönen, Mika and Kathiresan, Sekar and Keavney, Bernard D. and Khaw, Kay-Tee and Knekt, Paul and Knight, Joanne and Kolcic, Ivana and Kooner, Jaspal S. and Koskinen, Seppo and Kristiansson, Kati and Kutalik, Zoltan and Laan, Maris and Larson, Marty and Launer, Lenore J. and Lehne, Benjamin and Lehtimäki, Terho and Liewald, David C. M. and Lin, Li and Lind, Lars and Lindgren, Cecilia M. and Liu, YongMei and Loos, Ruth J. F. and Lopez, Lorna M. and Lu, Yingchang and Lyytikäinen, Leo-Pekka and Mahajan, Anubha and Mamasoula, Chrysovalanto and Marrugat, Jaume and Marten, Jonathan and Milaneschi, Yuri and Morgan, Anna and Morris, Andrew P. and Morrison, Alanna C. and Munson, Peter J. and Nalls, Mike A. and Nandakumar, Priyanka and Nelson, Christopher P. and Niiranen, Teemu and Nolte, Ilja M. and Nutile, Teresa and Oldehinkel, Albertine J. and Oostra, Ben A. and O’Reilly, Paul F. and Org, Elin and Padmanabhan, Sandosh and Palmas, Walter and Palotie, Aarno and Pattie, Alison and Penninx, Brenda W. J. H. and Perola, Markus and Peters, Annette and Polasek, Ozren and Pramstaller, Peter P. and Nguyen, Quang Tri and Raitakari, Olli T. and Ren, Meixia and Rettig, Rainer and Rice, Kenneth and Ridker, Paul M. and Ried, Janina S. and Riese, Harriëtte and Ripatti, Samuli and Robino, Antonietta and Rose, Lynda M. and Rotter, Jerome I. and Rudan, Igor and Ruggiero, Daniela and Saba, Yasaman and Sala, Cinzia F. and Salomaa, Veikko and Samani, Nilesh J. and Sarin, Antti-Pekka and Schmidt, Reinhold and Schmidt, Helena and Shrine, Nick and Siscovick, David and Smith, Albert V. and Snieder, Harold and Sõber, Siim and Sorice, Rossella and Starr, John M. and Stott, David J. and Strachan, David P. and Strawbridge, Rona J. and Sundström, Johan and Swertz, Morris A. and Taylor, Kent D. and Teumer, Alexander and Tobin, Martin D. and Tomaszewski, Maciej and Toniolo, Daniela and Traglia, Michela and Trompet, Stella and Tuomilehto, Jaakko and Tzourio, Christophe and Uitterlinden, André G. and Vaez, Ahmad and van der Most, Peter J. and van Duijn, Cornelia M. and Vergnaud, Anne-Claire and Verwoert, Germaine C. and Vitart, Veronique and Völker, Uwe and Vollenweider, Peter and Vuckovic, Dragana and Watkins, Hugh and Wild, Sarah H. and Willemsen, Gonneke and Wilson, James F. and Wright, Alan F. and Yao, Jie and Zemunik, Tatijana and Zhang, Weihua and Attia, John R. and Butterworth, Adam S. and Chasman, Daniel I. and Conen, David and Cucca, Francesco and Danesh, John and Hayward, Caroline and Howson, Joanna M. M. and Laakso, Markku and Lakatta, Edward G. and Langenberg, Claudia and Melander, Olle and Mook-Kanamori, Dennis O. and Palmer, Colin N. A. and Risch, Lorenz and Scott, Robert A. and Scott, Rodney J. and Sever, Peter and Spector, Tim D. and van der Harst, Pim and Wareham, Nicholas J. and Zeggini, Eleftheria and Levy, Daniel and Munroe, Patricia B. and Newton-Cheh, Christopher and Brown, Morris J. and Metspalu, Andres and Hung, Adriana M. and O’Donnell, Christopher J. and Edwards, Todd L. and Psaty, Bruce M. and Tzoulaki, Ioanna and Barnes, Michael R. and Wain, Louise V. and Elliott, Paul and Caulfield, Mark J. (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10). pp. 1412-1425. ISSN 1061-4036

Preview

Download (2MB) | Preview

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Item Type:	Article
Keywords:	Genetic; analysis; 1 million people; identifies; blood pressure traits; loci associated; 535;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17109
Identification Number:	https://doi.org/10.1038/s41588-018-0205-x
Depositing User:	Lorna Lopez
Date Deposited:	18 Apr 2023 10:30
Journal or Publication Title:	Nature Genetics
Publisher:	Nature Research
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads