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    Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS)

    Ma, Christopher and Schoepfer, Alain M. and Dellon, Evan S. and Bredenoord, Albert J. and Chehade, Mirna and Collins, Margaret H. and Feagan, Brian G. and Furuta, Glenn T. and Gupta, Sandeep K. and Hirano, Ikuo and Jairath, Vipul and Katzka, David A. and Pai, Rish K. and Rothenberg, Marc E. and Straumann, Alex and Aceves, Seema S. and Alexander, Jeffrey A. and Arva, Nicoleta C. and Atkins, Dan and Biedermann, Luc and Blanchard, Carine and Cianferoni, Antonella and Ciriza de los Rios, Constanza and Clayton, Frederic and Davis, Carla M. and de Bortoli, Nicola and Dias, Jorge A. and Falk, Gary W. and Genta, Robert M. and Ghaffari, Gisoo and Gonsalves, Nirmala and Greuter, Thomas and Hopp, Russell and Hsu Blatman, Karen S. and Jensen, Elizabeth T. and Johnston, Doug and Kagalwalla, Amir F. and Larsson, Helen M. and Leung, John and Louis, Hubert and Masterson, Joanne C. and Menard-Katcher, Calies and Menard-Katcher, Paul A. and Moawad, Fouad J. and Muir, Amanda B. and Mukkada, Vincent A. and Penagini, Roberto and Pesek, Robert D. and Peterson, Kathryn and Putnam, Philip E. and Ravelli, Alberto and Savarino, Edoardo V. and Schlag, Christoph and Schreiner, Philipp and Simon, Dagmar and Smyrk, Thomas C. and Spergel, Jonathan M. and Taft, Tiffany H. and Terreehorst, Ingrid and Vanuytsel, Tim and Venter, Carina and Vieira, Mario C. and Vieth, Michael and Vlieg-Boerstra, Berber and von Arnim, Ulrike and Walker, Marjorie M. and Wechsler, Joshua B. and Woodland, Philip and Woosley, John T. and Yang, Guang-Yu and Zevit, Noam and Safroneeva, Ekaterina (2022) Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS). Journal of Allergy and Clinical Immunology, 149 (2). pp. 659-670. ISSN 1097-6825

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    Background: End points used to determine treatment efficacy in eosinophilic esophagitis (EoE) have evolved over time. With multiple novel therapies in development for EoE, harmonization of outcomes measures will facilitate evidence synthesis and appraisal when comparing different treatments. Objective: We sought to develop a core outcome set (COS) for controlled and observational studies of pharmacologic and diet interventions in adult and pediatric patients with EoE. Methods: Candidate outcomes were generated from systematic literature reviews and patient engagement interviews and surveys. Consensus was established using an iterative Delphi process, with items voted on using a 9-point Likert scale and with feedback from other participants to allow score refinement.

    Item Type: Article
    Keywords: Development; core outcome; therapeutic studies; eosinophilic esophagitis; COREOS;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17152
    Identification Number:
    Depositing User: Joanne Masterson
    Date Deposited: 08 May 2023 10:57
    Journal or Publication Title: Journal of Allergy and Clinical Immunology
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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