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Nature Neuroscience, 19 (12). pp. 1569-1582. ISSN 1097-6256

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Abstract

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five novel loci for intracranial volume and confirmed two known signals. Four of the loci are also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (ρgenetic=0.748), which indicated a similar genetic background and allowed for the identification of four additional loci.

Item Type:	Article
Keywords:	Novel; genetic loci; human; intracranial; volume; identified; genome-wide; association;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17221
Identification Number:	https://doi.org/10.1038/nn.4398
Depositing User:	Lorna Lopez
Date Deposited:	24 May 2023 10:37
Journal or Publication Title:	Nature Neuroscience
Publisher:	Nature Research
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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