Lyall, Donald M. and Lopez, Lorna M. and Bastin, Mark E. and Maniega, Susana Muñoz and Penke, Lars and Valdés Hernández, Maria del C. and Royle, Natalie A. and Starr, John M. and Porteous, David. J. and Wardlaw, Joanna M. and Deary, Ian J. (2013) ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936. Behavior Genetics, 43 (1). pp. 13-23. ISSN 0001-8244

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Abstract

The non-synonymous mutations arg16gly (rs1042713) and gln27glu (rs1042714) in the adrenergic b-2 receptor gene (ADRB2) have been associated with cognitive function and brain white matter integrity. The current study aimed to replicate these findings and expand them to a broader range of cognitive and brain phenotypes. The sample used is a community-dwelling group of older people, the Lothian Birth Cohort 1936. They had been assessed cognitively at age 11 years, and undertook further cognitive assessments and brain diffusion MRI tractography in older age. The sample size range for cognitive function variables was N = 686–765, and for neuroimaging variables was N = 488–587. Previously-reported findings with these genetic variants did not replicate in this cohort. Novel, nominally significant associations were observed; notably, the integrity of the left arcuate fasciculus mediated the association between rs1042714 and the Digit Symbol Coding test of information processing speed. No significant associations of cognitive and brain phenotypes with ADRB2 variants survived correction for false discovery rate. Previous findings may therefore have been subject to type 1 error. Further study into links between ADRB2, cognitive function and brain white matter integrity is required.

Item Type:	Article
Keywords:	Intelligence; White matter; Cognitive ageing; Diffusion MRI; Tractography; ADRB2; Processing speed;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17249
Identification Number:	https://doi.org/10.1007/s10519-012-9570-x
Depositing User:	Lorna Lopez
Date Deposited:	29 May 2023 15:01
Journal or Publication Title:	Behavior Genetics
Publisher:	Springer
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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