Pradhan, Arnab and Ma, Qinxi and de Assis, Leandro J. and Leaves, Ian and Larcombe, Daniel E. and Rodriguez Rondon, Alejandra V. and Nev, Olga A. and Brown, Alistair J.P.
(2021)
Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens.
Trends in Microbiology, 29 (5).
pp. 416-427.
ISSN 0966-842X
Abstract
In certain niches, microbes encounter environmental challenges that are temporally linked. In such cases, microbial fitness is enhanced by the evolution of anticipatory responses where the initial challenge simultaneously activates pre-emptive protection against the second impending challenge. The accumulation of anticipatory responses in domesticated yeasts, which have been termed 'adaptive prediction', has led to the emergence of 'core stress responses' that provide stress cross-protection. Protective anticipatory responses also seem to be common in fungal pathogens of humans. These responses reflect the selective pressures that these fungi have faced relatively recently in their evolutionary history. Consequently,
some pathogens have evolved 'core environmental responses' which exploit host signals to trigger immune evasion strategies that protect them against imminent immune attack.
| Item Type: |
Article
|
| Additional Information: |
Cite as: Arnab Pradhan, Qinxi Ma, Leandro J. de Assis, Ian Leaves, Daniel E. Larcombe, Alejandra V. Rodriguez Rondon, Olga A. Nev, Alistair J.P. Brown,
Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens,
Trends in Microbiology,
Volume 29, Issue 5,
2021,
Pages 416-427,
ISSN 0966-842X,
https://doi.org/10.1016/j.tim.2020.09.010 |
| Keywords: |
fungal pathogenicity;immune evasion;stress responses;core environmental responses;adaptive prediction |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
17258 |
| Identification Number: |
https://doi.org/10.1016/j.tim.2020.09.010 |
| Depositing User: |
Mr LJ de Assis
|
| Date Deposited: |
01 Jun 2023 08:59 |
| Journal or Publication Title: |
Trends in Microbiology |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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