McCarthy, Cormac and O'Donnell, Cliona P and Kelly, Neil E Wrigley and O'Shea, Donal and Hogan, Andrew E. (2021) COVID-19 severity and obesity: are MAIT cells a factor? The Lancet Respiratory Medicine, 9 (5). pp. 445-447. ISSN 2213-2600
|
Download (742kB)
| Preview
|
Abstract
People with obesity have an increased risk of severe COVID-19: a meta-analysis by Popkin and colleagues1 found that the odds ratio of people with obesity being hospitalised with COVID-19 was 2·13 when compared with those without obesity, and mortality was 48% higher in patients with obesity than in those without. This increased risk of severe disease is linked to higher rates of metabolic and cardiovascular complications.2 Another major contributing factor is the presence of substantial immune dysregulation and chronic systemic inflammation. Obesity is associated with increased levels of numerous inflammatory mediators, including interleukin (IL)-1, IL-6, IL-17, and tumour necrosis factor α.3 These cytokines are also implicated in the pathogenesis of COVID-19.4 In addition to inflammation, obesity is associated with important defects in immune cells tasked with host protection, including natural killer cells and mucosal associated invariant T (MAIT) cells.5,6
| Item Type: | Article |
|---|---|
| Additional Information: | Cite as: McCarthy C, O'Donnell CP, Kelly NEW, O'Shea D, Hogan AE. COVID-19 severity and obesity: are MAIT cells a factor? Lancet Respir Med. 2021 May;9(5):445-447. doi: 10.1016/S2213-2600(21)00140-5. Epub 2021 Apr 9. PMID: 33844997; PMCID: PMC8040652. |
| Keywords: | COVID-19;obesity;immune dysregulation; chronic systemic inflammation |
| Academic Unit: | Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute |
| Item ID: | 17293 |
| Identification Number: | https://doi.org/10.1016/S2213-2600(21)00140-5 |
| Depositing User: | Andrew Hogan |
| Date Deposited: | 08 Jun 2023 10:13 |
| Journal or Publication Title: | The Lancet Respiratory Medicine |
| Publisher: | Elsevier |
| Refereed: | Yes |
| URI: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
Repository Staff Only(login required)
 |
Item control page |
Downloads
Downloads per month over past year
Altmetric
Altmetric