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    The IRX(3)some factor in macrophages

    Moynagh, Paul N. and Hogan, Andrew E. (2021) The IRX(3)some factor in macrophages. Nature Immunology, 22 (10). pp. 1203-1204. ISSN 1529-2908

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    Obesity is a major global healthcare concern, with over 600 million adults worldwide currently classified as living with the condition1. Obesity has been linked to numerous comorbid conditions ranging from type 2 diabetes mellitus and cardiovascular disease to a high percentage of cancers2 . A core link between obesity and these comorbidities is chronic inflammation3 , and thus the quest to understand the initiators and drivers of this pathogenic process in people with obesity is critically important and may lead to future therapeutics. In this issue of Nature Immunology, Qiu and colleagues identify the transcription factor IRX3 as a key driver of pro-inflammatory cytokine production in macrophages, which in mouse models is associated with repression of lipolysis and thermogenesis, leading to increased bodyweight and poor metabolic health4.

    Item Type: Article
    Additional Information: Cite as: Moynagh, P.N., Hogan, A.E. The IRX(3)some factor in macrophages. Nat Immunol 22, 1203–1204 (2021).
    Keywords: Obesity;IRX3;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17295
    Identification Number:
    Depositing User: Andrew Hogan
    Date Deposited: 08 Jun 2023 13:12
    Journal or Publication Title: Nature Immunology
    Publisher: Nature Immunology
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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