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    Longevity candidate genes and their association with personality traits in the elderly

    Luciano, Michelle and Lopez, Lorna M. and de Moor, Marleen H.M. and Harris, Sarah E. and Davies, Gail and Nutile, Teresa and Krueger, Robert F. and Esko, Tõnu and Schlessinger, David and Toshiko, Tanaka and Derringer, Jaime L. and Realo, Anu and Hansell, Narelle K. and Pergadia, Michele L. and Pesonen, Anu-Katriina and Sanna, Serena and Terracciano, Antonio and Madden, Pamela A.F. and Penninx, Brenda and Spinhoven, Philip and Hartman, Catherina A. and Oostra, Ben A. and Janssens, A. Cecile J.W. and Eriksson, Johan G. and Starr, John M. and Cannas, Alessandra and Ferrucci, Luigi and Metspalu, Andres and Wright, Margeret J. and Heath, Andrew C. and van Duijn, Cornelia M. and Bierut, Laura J. and Raikkonen, Katri and Martin, Nicholas G. and Ciullo, Marina and Rujescu, Dan and Boomsma, Dorret I. and Deary, Ian J. (2011) Longevity candidate genes and their association with personality traits in the elderly. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B (2). pp. 192-200. ISSN 15524841

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    Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1 and SYNJ2) were typed in over one thousand 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (p < 0.0002), but there was an over-representation of nominally significant (p < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17 106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged > 60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.

    Item Type: Article
    Keywords: NEO personality; IPIP personality; anxiety; depressive symptoms; ageing; genetics;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17316
    Identification Number:
    Depositing User: Lorna Lopez
    Date Deposited: 14 Jun 2023 11:39
    Journal or Publication Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
    Publisher: Wiley
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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