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    Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens

    Evans, Andris and Kavanagh, Kevin A. (2021) Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens. Journal of Medical Microbiology, 70 (5). ISSN 0022-2615

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    Antimicrobial resistance (AMR) is one of the greatest global health challenges of modern times and its prevalence is rising worldwide. AMR within bacteria reduces the efficacy of antibiotics and increases both the morbidity and the mortality associated with bacterial infections. Despite this growing risk, few antibiotics with a novel mode of action are being produced, leading to a lack of antibiotics that can effectively treat bacterial infections with AMR. Metals have a history of antibacterial use but upon the discovery of antibiotics, often became overlooked as antibacterial agents. Meanwhile, metal-based complexes have been used as treatments for other diseases, such as the gold-containing drug auranofin, used to treat rheumatoid arthritis. Metal-based antibacterial compounds have novel modes of action that provide an advantage for the treatment of bacterial infections with resistance to conventional antibiotics. In this review, the antibacterial activity, mode of action, and potential for systemic use of a number of metal-based antibacterial complexes are discussed. The current limitations of these compounds are highlighted to determine if metal-based agents are a potential solution for the treatment of bacterial infections, especially those resistant to conventional antibiotics

    Item Type: Article
    Additional Information: Evans, A. & Kavanagh, K.A. 2021, "Evaluation of metal-based antimicrobial compounds for the treatment of bacterial pathogens", Journal of medical microbiology, vol. 70, no. 5.
    Keywords: bacterial pathogens; antibiotics; resistance; metal-based compounds; infection; therapy
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17320
    Identification Number:
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 15 Jun 2023 08:12
    Journal or Publication Title: Journal of Medical Microbiology
    Publisher: Microbiology Society
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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