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    Meta-analysis of genome-wide association studies for personality

    de Moor, M H M and Costa, P T and Terracciano, A and Krueger, R F and de Geus, E J C and Toshiko, T and Penninx, B W J H and Esko, T and Madden, P A F and Derringer, J and Amin, N and Willemsen, G and Hottenga, J-J and Distel, M A and Uda, M and Sanna, S and Spinhoven, P and Hartman, C A and Sullivan, P and Realo, A and Allik, J and Heath, A C and Pergadia, M L and Agrawal, A and Lin, P and Grucza, R and Nutile, T and Ciullo, M and Rujescu, D and Giegling, I and Konte, B and Widen, E and Cousminer, D L and Eriksson, J G and Palotie, A and Peltonen, L and Luciano, M and Tenesa, A and Davies, G and Lopez, Lorna M. and Hansell, N K and Medland, S E and Ferrucci, L and Schlessinger, D and Montgomery, G W and Wright, M J and Aulchenko, Y S and Janssens, A C J W and Oostra, B A and Metspalu, A and Abecasis, G R and Deary, I J and Räikkönen, K and Bierut, L J and Martin, N G and van Duijn, C M and Boomsma, D I (2012) Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry, 17 (3). pp. 337-349. ISSN 1359-4184

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    Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17 375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ∼2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P=2.8 × 10−8 and 3.1 × 10−8) and for Conscientiousness in the brain-expressed KATNAL2 gene on 18q21.1 (rs2576037, P=4.9 × 10−8). We further conducted a gene-based test that confirmed the association of KATNAL2 to Conscientiousness. In silico replication did not, however, show significant associations of the top SNPs with Openness and Conscientiousness, although the direction of effect of the KATNAL2 SNP on Conscientiousness was consistent in all replication samples. Larger scale GWA studies and alternative approaches are required for confirmation of KATNAL2 as a novel gene affecting Conscientiousness.

    Item Type: Article
    Keywords: personality; Five-Factor Model; genome-wide association; meta-analysis; genetic variants;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17332
    Identification Number:
    Depositing User: Lorna Lopez
    Date Deposited: 19 Jun 2023 11:28
    Journal or Publication Title: Molecular Psychiatry
    Publisher: Nature Publishing Group
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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