Ma, Christopher and Schoepfer, Alain M. and Safroneeva, Ekaterina and Ma, Christopher and Schoepfer, Alain M. and Dellon, Evan S. and Bredenoord, Albert J. and Chehade, Mirna and Collins, Margaret H. and Feagan, Brian G. and Furuta, Glenn T. and Gupta, Sandeep K. and Hirano, Ikuo and Jairath, Vipul and Katzka, David A. and Pai, Rish K. and Rothenberg, Marc E. and Straumann, Alex and Aceves, Seema S. and Alexander, Jeffrey A. and Arva, Nicoleta C. and Atkins, Dan and Biedermann, Luc and Blanchard, Carine and Cianferoni, Antonella and Ciriza de los Rios, Constanza and Clayton, Frederic and Davis, Carla M. and de Bortoli, Nicola and Dias, Jorge A. and Falk, Gary W. and Genta, Robert M. and Ghaffari, Gisoo and Gonsalves, Nirmala and Greuter, Thomas and Hopp, Russell and Hsu Blatman, Karen S. and Jensen, Elizabeth T. and Johnston, Doug and Kagalwalla, Amir F. and Larsson, Helen M. and Leung, John and Louis, Hubert and Masterson, Joanne C. and Menard-Katcher, Calies and Menard-Katcher, Paul A. and Moawad, Fouad J. and Muir, Amanda B. and Mukkada, Vincent A. and Penagini, Roberto and Pesek, Robert D. and Peterson, Kathryn and Putnam, Philip E. and Ravelli, Alberto and Savarino, Edoardo V. and Schlag, Christoph and Schreiner, Philipp and Simon, Dagmar and Smyrk, Thomas C. and Spergel, Jonathan M. and Taft, Tiffany H. and Terreehorst, Ingrid and Vanuytsel, Tim and Venter, Carina and Vieira, Mario C. and Vieth, Michael and Vlieg-Boerstra, Berber and von Arnim, Ulrike and Walker, Marjorie M. and Wechsler, Joshua B. and Woodland, Philip and Woosley, John T. and Yang, Guang-Yu and Zevit, Noam and Safroneeva, Ekaterina (2021) A Summary of the Meetings of the Development of a Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) International Multidisciplinary Consensus. Gastroenterology, 161 (3). pp. 778-784. ISSN 0016-5085

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Abstract

The Core Outcome Set for Therapeutic Studies in Eosinophilic Esophagitis (COREOS) collaborators are a group of more than 70 gastroenterologists, pathologists, allergists, researchers, dietitians, psychologists, and methodologists who convened in a series of in-person and virtual meetings between 2018 and 2020 with the aim of developing a core outcome set (COS) for use in therapeutic studies of pharmacologic and dietary therapies for the treatment of eosinophilic esophagitis (EoE). Given heterogeneity in reported outcomes and uncertainties regarding the most appropriate end points for use in both randomized controlled trials (RCTs) and observational studies involving EoE patients, the EoE experts launched the COREOS exercise in 2018 to standardize outcome definitions using methods established by the Core Outcome Measures in Effectiveness Trials (COMET) initiative.1,2 The COS was developed using a multiphase approach, which is summarized in Figure 1. In the first phase, systematic reviews of the literature and patient engagement surveys were conducted to identify candidate outcomes that have been previously measured and are important to patients with EoE. Next, this information was used to build a framework of different outcome domains, and working groups for each domain were assembled to review the literature for relevant end points.3–6 The relative importance of these domains was categorized in a Delphi survey as core, important, and research agenda domains, and discussed in a moderated in-person meeting on May 17, 2019 at Digestive Disease Week (San Diego, CA). In phase 3, a comprehensive list of outcome measures within each of the core domains was evaluated by the COREOS collaborators in a 2-round Delphi survey and, finally, outcomes were ratified in a virtual meeting on December 8, 2020. In this meeting summary, we highlight the major points of discussion that occurred during the development of the EoE COS.

Item Type:	Article
Additional Information:	Cite as: Christopher Ma, Alain M. Schoepfer, Evan S. Dellon, Albert J. Bredenoord, Mirna Chehade, Margaret H. Collins, Brian G. Feagan, Glenn T. Furuta, Sandeep K. Gupta, Ikuo Hirano, Vipul Jairath, David A. Katzka, Rish K. Pai, Marc E. Rothenberg, Alex Straumann, Seema S. Aceves, Jeffrey A. Alexander, Nicoleta C. Arva, Dan Atkins, Luc Biedermann, Carine Blanchard, Antonella Cianferoni, Constanza Ciriza de los Rios, Frederic Clayton, Carla M. Davis, Nicola de Bortoli, Jorge A. Dias, Gary W. Falk, Robert M. Genta, Gisoo Ghaffari, Nirmala Gonsalves, Thomas Greuter, Russell Hopp, Karen S. Hsu Blatman, Elizabeth T. Jensen, Doug Johnston, Amir F. Kagalwalla, Helen M. Larsson, John Leung, Hubert Louis, Joanne C. Masterson, Calies Menard-Katcher, Paul A. Menard-Katcher, Fouad J. Moawad, Amanda B. Muir, Vincent A. Mukkada, Roberto Penagini, Robert D. Pesek, Kathryn Peterson, Philip E. Putnam, Alberto Ravelli, Edoardo V. Savarino, Christoph Schlag, Philipp Schreiner, Dagmar Simon, Thomas C. Smyrk, Jonathan M. Spergel, Tiffany H. Taft, Ingrid Terreehorst, Tim Vanuytsel, Carina Venter, Mario C. Vieira, Michael Vieth, Berber Vlieg-Boerstra, Ulrike von Arnim, Marjorie M. Walker, Joshua B. Wechsler, Philip Woodland, John T. Woosley, Guang-Yu Yang, Noam Zevit, Ekaterina Safroneeva, Development of a core outcome set for therapeutic studies in eosinophilic esophagitis (COREOS), Journal of Allergy and Clinical Immunology, Volume 149, Issue 2, 2022, Pages 659-670, ISSN 0091-6749, https://doi.org/10.1016/j.jaci.2021.07.001.
Keywords:	Eosinophilic Esophagitis; Outcomes; Clinical Trials; End Points; Histology; Histopathology; Endoscopy; Symptoms; Patient-Reported Outcomes; Quality of Life;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17338
Identification Number:	https://doi.org/10.1053/j.gastro.2021.04.081
Depositing User:	Joanne Masterson
Date Deposited:	22 Jun 2023 07:57
Journal or Publication Title:	Gastroenterology
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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