Batten, Isabella and Robinson, Mark W. and White, Arthur and Walsh, Cathal and Fazekas, Barbara and Wyse, Jason and Buettner, Antonia and D’Arcy, Suzanne and Greenan, Emily and Murphy, Conor C. and Wigston, Zoe and Gabhann-Dromgoole, Joan Ní and Vital, Edward M. and Little, Mark A. and Bourke, Nollaig M. (2021) Investigation of type I interferon responses in ANCA-associated vasculitis. Scientific Reports, 11 (1). ISSN 2045-2322

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Abstract

Type I interferon (IFN) dysregulation is a major contributory factor in the development of several autoimmune diseases, termed type I interferonopathies, and is thought to be the pathogenic link with chronic infammation in these conditions. Anti-neutrophil cytoplasmic antibody (ANCA)-Associated Vasculitis (AAV) is an autoimmune disease characterised by necrotising infammation of small blood vessels. The underlying biology of AAV is not well understood, however several studies have noted abnormalities in type I IFN responses. We hypothesised that type I IFN responses are systemically dysregulated in AAV, consistent with features of a type I interferonopathy. To investigate this, we measured the expression of seven interferon regulated genes (IRGs) (ISG15, SIGLEC1, STAT1, RSAD2, IFI27, IFI44L and IFIT1) in peripheral blood samples, as well as three type I IFN regulated proteins (CXCL10, MCP-1 and CCL19) in serum samples from AAV patients, healthy controls and disease controls. We found no difference in type I IFN regulated gene or protein expression between AAV patients and healthy controls. Furthermore, IRG and IFN regulated protein expression did not correlate with clinical measurements of disease activity in AAV patients. Thus, we conclude that systemic type I IFN responses are not key drivers of AAV pathogenesis and AAV should not be considered a type I interferonopathy.

Item Type:	Article
Additional Information:	Cite as: Batten, I., Robinson, M.W., White, A. et al. Investigation of type I interferon responses in ANCA-associated vasculitis. Sci Rep 11, 8272 (2021). https://doi.org/10.1038/s41598-021-87760-4
Keywords:	autoimmune diseases; Type I interferon;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17347
Identification Number:	https://doi.org/10.1038/s41598-021-87760-4
Depositing User:	Mark Robinson
Date Deposited:	22 Jun 2023 13:07
Journal or Publication Title:	Scientific Reports
Publisher:	Nature
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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