Ahmed, Ola and Robinson, Mark W. and O’Farrelly, Cliona (2021) Inflammatory processes in the liver: divergent roles in homeostasis and pathology. Cellular & Molecular Immunology, 18 (6). pp. 1375-1386. ISSN 1672-7681

Preview

Download (1MB) | Preview

Abstract

The hepatic immune system is designed to tolerate diverse harmless foreign moieties to maintain homeostasis in the healthy liver. Constant priming and regulation ensure that appropriate immune activation occurs when challenged by pathogens and tissue damage. Failure to accurately discriminate, regulate, or effectively resolve inflammation offsets this balance, jeopardizing overall tissue health resulting from an either overly tolerant or an overactive inflammatory response. Compelling scientific and clinical evidence links dysregulated hepatic immune and inflammatory responses upon sterile injury to several pathological conditions in the liver, particularly nonalcoholic steatohepatitis and ischemia-reperfusion injury. Murine and human studies have described interactions between diverse immune repertoires and nonhematopoietic cell populations in both physiological and pathological activities in the liver, although the molecular mechanisms driving these associations are not clearly understood. Here, we review the dynamic roles of inflammatory mediators in responses to sterile injury in the context of homeostasis and disease, the clinical implications of dysregulated hepatic immune activity and therapeutic developments to regulate liver-specific immunity.

Item Type:	Article
Additional Information:	Cite as:Ahmed, O., Robinson, M.W. & O'Farrelly, C. 2021, "Inflammatory processes in the liver: divergent roles in homeostasis and pathology", Cellular & molecular immunology, vol. 18, no. 6, pp. 1375-1386.
Keywords:	Immune system; liver; homeostasis
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17348
Identification Number:	https://doi.org/10.1038/s41423-021-00639-2
Depositing User:	Mark Robinson
Date Deposited:	22 Jun 2023 13:16
Journal or Publication Title:	Cellular & Molecular Immunology
Publisher:	Nature Publishing Group
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads