Funk, Tjede and Pharris, Anastasia and Spiteri, Gianfranco and Bundle, Nick and Melidou, Angeliki and Carr, Michael and Gonzalez, Gabriel and Garcia-Leon, Alejandro and Crispie, Fiona and O’Connor, Lois and Murphy, Niamh and Mossong, Joël and Vergison, Anne and Wienecke-Baldacchino, Anke K. and Abdelrahman, Tamir and Riccardo, Flavia and Stefanelli, Paola and Di Martino, Angela and Bella, Antonino and Lo Presti, Alessandra and Casaca, Pedro and Moreno, Joana and Borges, Vítor and Isidro, Joana and Ferreira, Rita and Gomes, João Paulo and Dotsenko, Liidia and Suija, Heleene and Epstein, Jevgenia and Sadikova, Olga and Sepp, Hanna and Ikonen, Niina and Savolainen-Kopra, Carita and Blomqvist, Soile and Möttönen, Teemu and Helve, Otto and Gomes-Dias, Joana and Adlhoch, Cornelia and Walsh, Fiona (2021) Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021. Eurosurveillance, 26 (16). ISSN 1560-7917

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Abstract

We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0–2.9; B.1.351: 3.6, 95% CI: 2.1–6.2; P.1: 2.6, 95% CI: 1.4–4.8) and B.1.1.7/SGTF and P.1 cases also for intensive care admission (B.1.1.7/SGTF: 2.3, 95% CI: 1.4–3.5; P.1: 2.2, 95% CI: 1.7–2.8). Here, we analyse coronavirus disease (COVID-19) cases infected with any of the three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC): B.1.1.7/S gene target failure (SGTF), B.1.351 or P.1. We compare them with cases reported as infected with non-VOC virus with a focus on disease severity.

Item Type:	Article
Additional Information:	Cite as: Funk Tjede, Pharris Anastasia, Spiteri Gianfranco, Bundle Nick, Melidou Angeliki, Carr Michael, Gonzalez Gabriel, Garcia-Leon Alejandro, Crispie Fiona, O’Connor Lois, Murphy Niamh, Mossong Joël, Vergison Anne, Wienecke-Baldacchino Anke K., Abdelrahman Tamir, Riccardo Flavia, Stefanelli Paola, Di Martino Angela, Bella Antonino, Lo Presti Alessandra, Casaca Pedro, Moreno Joana, Borges Vítor, Isidro Joana, Ferreira Rita, Gomes João Paulo, Dotsenko Liidia, Suija Heleene, Epstein Jevgenia, Sadikova Olga, Sepp Hanna, Ikonen Niina, Savolainen-Kopra Carita, Blomqvist Soile, Möttönen Teemu, Helve Otto, Gomes-Dias Joana, Adlhoch Cornelia, on behalf of COVID study groups. Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021. Euro Surveill. 2021;26(16):pii=2100348. https://doi.org/10.2807/1560-7917.ES.2021.26.16.2100348
Keywords:	SARS-CoV-2; Covid-19; antibodies;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17350
Identification Number:	https://doi.org/10.2807/1560-7917.ES.2021.26.16.2100348
Depositing User:	Fiona Walsh
Date Deposited:	22 Jun 2023 13:56
Journal or Publication Title:	Eurosurveillance
Publisher:	Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS)
Refereed:	Yes
URI:
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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