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    The Virtual Lab Approach to Pharmacokinetics: Design Principles and Concepts.

    Huisinga, Wilhelm and Telgmann, Regina and Wulkow, Michael (2006) The Virtual Lab Approach to Pharmacokinetics: Design Principles and Concepts. Drugs Discovery Today, 11 (17-18). pp. 773-862. ISSN 1359-6446

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    Modeling and simulation in pharmacokinetics has has turned into the focus of pharmaceutical companies, driven by the emerging consensus that in silico predictions combined with in vitro data have the potential of significantly increasing insight into pharmacokinetic processes. To adequately support in silico methodology, software tools need to be user-friendly and, at the same time, flexible. In brief, the software has to allow the realization of modeling ideas that are beyond current knowledge – in the form of a virtual lab. We present and discuss the necessary design principles and concepts. These have been implemented in the software package MEDICI-PK to demonstrate its feasibility and advantages.

    Item Type: Article
    Keywords: Virtual lab; In silico drug discovery; PBPK; Systems biology; Disease modeling; Hamilton Institute.
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Faculty of Science and Engineering > Mathematics and Statistics
    Item ID: 1739
    Identification Number:
    Depositing User: Hamilton Editor
    Date Deposited: 04 Jan 2010 16:46
    Journal or Publication Title: Drugs Discovery Today
    Publisher: Elsevier
    Refereed: No
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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