Penke, Lars and Maniega, Susana Muñoz and Lopez, Lorna M. and Murray, Catherine and Gow, Alan J. and Clayden, Jonathan D. and Bastin, Mark E. and Wardlaw, Joanna M. and Deary, Ian J. (2010) White Matter Integrity in the Splenium of the Corpus Callosum is Related to Successful Cognitive Aging and Partly Mediates the Protective Effect of an Ancestral Polymorphism in ADRB2. Behavior Genetics, 40 (2). pp. 146-156. ISSN 0001-8244

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Abstract

It has recently been reported that the evolutionarily ancestral alleles of two functional polymorphisms in the b2-adrenergic receptor gene (ADRB2) were related to higher cognitive ability in the 70 year old participants of the Lothian Birth Cohort 1936 (LBC1936). One emerging important factor in cognitive aging is the integrity of white matter tracts in the brain. Here, we used diffusion tensor MRI-based tractography to assess the integrity of eight white matter tracts in a subsample of the LBC1936. Higher integrity of the splenium of the corpus callosum predicted better cognitive ability in old age, even after controlling for IQ at age 11. Also, the ancestral allele of one ADRB2 SNP was associated with both splenium integrity and better cognitive aging. While the effects of the SNP and splenium integrity on cognitive aging were largely independent, there was some evidence for a partial mediation effect of ADRB2 status via splenium integrity.

Item Type:	Article
Keywords:	Cognitive aging; Diffusion tensor MRI; White matter tractography; Splenium corpus callosum; ADRB2; Comparative genomics;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17415
Identification Number:	https://doi.org/10.1007/s10519-009-9318-4
Depositing User:	Lorna Lopez
Date Deposited:	17 Jul 2023 14:52
Journal or Publication Title:	Behavior Genetics
Publisher:	Wiley
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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